ArticleJournal of bacteriology2013
YfdW and YfdU are required for oxalate-induced acid tolerance in Escherichia coli K-12.
Article in Journal of bacteriology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Quantitative transcriptomic and metabolic analyses reveal the roles of RpoS and Crp in the acid resistance system 1 inMicrobiology spectrum · 2026Article
- Prevalence of oxalotrophy in the human microbiome.BMC genomics · 2025Article
- Biosynthesis and assembly of hydrogenase [NiFe]-cofactor: recent advances and perspectives.Metallomics : integrated biometal science · 2025Review
- Response ofMicroorganisms · 2024Review
- Multiomics Assessment of the Gut Microbiome in Rare Hyperoxaluric Conditions.Kidney international reports · 2024Article
- EvgS/EvgA, the unorthodox two-component system regulating bacterial multiple resistance.Applied and environmental microbiology · 2023Review
- Systematic Identification of CpxRA-Regulated Genes and Their Roles in Escherichia coli Stress Response.mSystems · 2022Article
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- Trees, fungi and bacteria: tripartite metatranscriptomics of a root microbiome responding to soil contamination.Microbiome · 2018Article
- Article
- Genome sequence of the acid-tolerantGenomics data · 2017Article
- Genome sequence of the copper resistant and acid-tolerantGenomics data · 2017Article
- Hyperoxaluria leads to dysbiosis and drives selective enrichment of oxalate metabolizing bacterial species in recurrent kidney stone endures.Scientific reports · 2016Article
- Characterization of mutations in the PAS domain of the EvgS sensor kinase selected by laboratory evolution for acid resistance in Escherichia coli.Molecular microbiology · 2014Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Escherichia coli has several mechanisms for surviving low-pH stress. We report that oxalic acid, a small-chain organic acid (SCOA), induces a moderate acid tolerance response (ATR) in two ways. Adaptation of E. coli K-12 at pH 5.5 with 50 mM oxalate and inclusion of 25 mM oxalate in pH 3.0 minimal challenge medium separately conferred protection, with 67% ± 7% and 87% ± 17% survival after 2 h, respectively. The combination of oxalate adaptation and oxalate supplementation in the challenge medium resulted in increased survival over adaptation or oxalate in the challenge medium alone. The enzymes YfdW, a formyl coenzyme A (CoA) transferase, and YfdU, an oxalyl-CoA decarboxylase, are required for the adaptation effect but not during challenge. Unlike other SCOAs, this oxalate ATR is not a part of the RpoS regulon but appears to be linked to the signal protein GadE. We theorize that this oxalate ATR could enhance the pathogenesis of virulent E. coli consumed with oxalate-containing foods like spinach.
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Registered trials
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