ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2013
Tbx1 is required for second heart field proliferation in zebrafish.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 61 citations in OpenAlex.
- Mitochondrial dysfunction underlies cardiac contractility and growth defects in a zebrafish model ofbioRxiv : the preprint server for biology · 2026Article
- Synergistic and independent roles for Nodal and FGF in zebrafish cardiac progenitor cell migration and asymmetric heart morphogenesis.Development (Cambridge, England) · 2025Article
- A systems genetics approach identifies roles for proteasome factors in heart development and congenital heart defects.PLoS genetics · 2025Article
- Tbx1-dependent and independent pathways promote six gene expression downstream of retinoic acid signaling to determine cardiomyocyte number in zebrafish.Developmental biology · 2025Article
- Retinoic acid promotes second heart field addition and regulates ventral aorta patterning in zebrafish.Developmental biology · 2025Article
- Nkx2.7 is a conserved regulator of craniofacial development.Nature communications · 2025Article
- Zebrafish arterial valve development occurs through direct differentiation of second heart field progenitors.Cardiovascular research · 2025Article
- Beyond genomic studies of congenital heart defects through systematic modelling and phenotyping.Disease models & mechanisms · 2024Article
- Gata6 functions in zebrafish endoderm to regulate late differentiating arterial pole cardiogenesis.Development (Cambridge, England) · 2024Article
- Article
- GATA4/5/6 family transcription factors are conserved determinants of cardiac versus pharyngeal mesoderm fate.Science advances · 2022Article
- From Stripes to a Beating Heart: Early Cardiac Development in Zebrafish.Journal of cardiovascular development and disease · 2021Review
- Mef2c factors are required for early but not late addition of cardiomyocytes to the ventricle.Developmental biology · 2021Article
- Cardiopharyngeal Progenitor Specification: Multiple Roads to the Heart and Head Muscles.Cold Spring Harbor perspectives in biology · 2020Review
- Cardiac function modulates endocardial cell dynamics to shape the cardiac outflow tract.Development (Cambridge, England) · 2020Article
- Formation and Growth of Cardiac Lymphatics during Embryonic Development, Heart Regeneration, and Disease.Cold Spring Harbor perspectives in biology · 2020Review
- Pbx4 limits heart size and fosters arch artery formation by partitioning second heart field progenitors and restricting proliferation.Development (Cambridge, England) · 2020Article
- Genetic deletion of gpr27 alters acylcarnitine metabolism, insulin sensitivity, and glucose homeostasis in zebrafish.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- A single-cell transcriptional roadmap for cardiopharyngeal fate diversification.Nature cell biology · 2019Article
- HDAC1-mediated repression of the retinoic acid-responsive gene ripply3 promotes second heart field development.PLoS genetics · 2019Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe mammalian outflow tract (OFT) and primitive right ventricle arise by accretion of newly differentiated cells to the arterial pole of the heart tube from multi-potent progenitor cells of the second heart field (SHF). While mounting evidence suggests that the genetic pathways regulating SHF development are highly conserved in zebrafish, this topic remains an active area of investigation.
resultsHere, we extend previous observations demonstrating that zebrafish tbx1 (van gogh, vgo) mutants show ventricular and OFT defects consistent with a conserved role in SHF-mediated cardiogenesis. Surprisingly, we reveal through double in situ analyses that tbx1 transcripts are excluded from cardiac progenitor cells and differentiated cardiomyocytes, suggesting a non-autonomous role in SHF development. Further, we find that the diminutive ventricle in vgo animals results from a 25% decrease in cardiomyocyte number that occurs subsequent to heart tube stages. Lastly, we report that although SHF progenitors are specified in the absence of Tbx1, they fail to be maintained due to compromised SHF progenitor cell proliferation.
conclusionsThese studies highlight conservation of Tbx1 function in zebrafish SHF biology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.