Evidence map›Paper›PMID 23335263›Full record

Trial reportResearch in nursing & health2013

Nutrition intervention to decrease symptoms in patients with advanced heart failure.

Terry A Lennie, Debra K Moser, Martha J Biddle, Darlene Welsh, Geza G Bruckner, D Travis Thomas, Mary Kay Rayens, Alison L Bailey

Open access · bronzeAbstract readEditorialRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Research in nursing & health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Article
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Terry A LennieCollege of Nursing, University of Kentucky, 751 Rose Street, Lexington, KY 40536-0232, USA.
Debra K Moser
Martha J Biddle
Darlene Welsh
Geza G Bruckner
D Travis Thomas
Mary Kay Rayens
Alison L Bailey
Marymount University · USUniversity of Kentucky · US

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
Kentucky Center for Clinical and Translational ScienceUL1TR000117 · NCATS · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2012 to 2015
$13.3M
KENTUCKY CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCEUL1RR033173 · NCRR · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2011 to 2011
$3.5M
Biobehavioral Intervention in Heart FailureR01NR008567 · NINR · UNIVERSITY OF KENTUCKY · PI MOSER, DEBRA KAY · 2004 to 2008
$1.5M
BMI, Nutrition, Inflammation and Heart Failure OutcomesR01NR009280 · NINR · UNIVERSITY OF KENTUCKY · PI LENNIE, TERRY A · 2005 to 2007
$1.5M
Nutrition Intervention to Reduce Symptoms in Patients with Advanced Heart FailureR01NR013430 · NINR · UNIVERSITY OF KENTUCKY · PI LENNIE, TERRY A · 2011 to 2014
$1.5M
Self-Management Pilot/Feasibility and Biobehavioral Outcomes CoreP20NR010679 · NINR · UNIVERSITY OF KENTUCKY · PI LENNIE, TERRY A · 2007 to 2011
$1.2M
Kentucky Center for Clinical and Translational ScienceKL2RR033171 · NCRR · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2011 to 2011
$302k
Kentucky Center for Clinical and Translational ScienceTL1RR033172 · NCRR · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2011 to 2011
$161k
NCATS NIH HHS UL1 TR000117NCATS NIH HHS UL1 TR001998NCRR NIH HHS KL2 RR033171NCRR NIH HHS TL1 RR033172NCRR NIH HHS TL1 RR033172,NCRR NIH HHS UL1 RR033173NCRR NIH HHS UL1RR033173NINR NIH HHS 1P20NR010679NINR NIH HHS P20 NR010679NINR NIH HHS R01 NR008567NINR NIH HHS R01NR008567NINR NIH HHS R01 NR009280NINR NIH HHS R01NR009280NINR NIH HHS R01 NR013430
6 · The paper itself

Abstract

For a majority of patients with advanced heart failure, there is a need for complementary, non-pharmacologic interventions that could be easily implemented by health care providers to provide palliative care. Three major pathologic pathways underlying heart failure symptoms have been identified: fluid overload, inflammation, and oxidative stress. Prior research has demonstrated that three nutrients-sodium, omega-3 fatty acids, and lycopene-can alter these pathologic pathways. Therefore, the purposes of this study are to test the effects of a 6-month nutrition intervention of dietary sodium reduction combined with supplementation of lycopene and omega-3 fatty acids on heart failure symptoms, health-related quality of life, and time to heart failure rehospitalization or all-cause death. The aims of this double blind-placebo controlled study are (1) to determine the effects of a 6-month nutrition intervention on symptom burden (edema, shortness of air, and fatigue) and health-related quality of life at 3 and 6 months, and time to heart failure rehospitalization or all-cause death over 12 months from baseline; (2) compare dietary sodium intake, inflammation, and markers of oxidative stress between the nutrition intervention group and a placebo group at 3 and 6 months; and (3) compare body weight, serum lycopene, and erythrocyte omega-3 index between the nutrition intervention group and a placebo group at 3 and 6 months. A total of 175 patients with advanced heart failure will be randomized to either the nutrition intervention or placebo group.

Indexed as

Quality of LifeBiomarkersCarotenoidsDietary SupplementsDiet, Sodium-RestrictedDinoprostFatty Acids, Omega-3FemaleHeart FailureHospitalizationHumansInflammationLycopeneMaleMalondialdehydeMiddle Aged8-epi-prostaglandin F2alphaBiomarkersCarotenoidsDinoprostFatty Acids, Omega-3LycopeneMalondialdehydeUric Acid

Identifiers

PMID23335263
PMCPMC4011634
OpenAlexW1979408889

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.