ArticleGenome biology and evolution2013
Dynamic evolution of endogenous retrovirus-derived genes expressed in bovine conceptuses during the period of placentation.
Article in Genome biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Update on endogenous retroviruses in cattle placenta.The Journal of reproduction and development · 2026Review
- Epithelial-Mesenchymal Transitions Leading to Conceptus Adhesion in Ruminants: Early Pregnancy Events in Cattle.International journal of molecular sciences · 2025Review
- Progressive Exaptation of Endogenous Retroviruses in Placental Evolution in Cattle.Biomolecules · 2023Review
- Review
- Leftovers of viruses in human physiology.Brain structure & function · 2021Review
- Novel endogenous retrovirus-derived transcript expressed in the bovine placenta is regulated by WNT signaling.The Biochemical journal · 2017Article
- Endometrial factors similarly induced by IFNT2 and IFNTc1 through transcription factor FOXS1.PloS one · 2017Article
- Conceptus implantation and placentation: molecules related to epithelial-mesenchymal transition, lymphocyte homing, endogenous retroviruses, and exosomes.Reproductive medicine and biology · 2016Review
- gEVE: a genome-based endogenous viral element database provides comprehensive viral protein-coding sequences in mammalian genomes.Database : the journal of biological databases and curation · 2016Article
- Recent advances in the study of active endogenous retrovirus envelope glycoproteins in the mammalian placenta.Virologica Sinica · 2015Review
- Review
- When Competing Viruses Unify: Evolution, Conservation, and Plasticity of Genetic Identities.Journal of molecular evolution · 2015Article
- Dispersal of an ancient retroposon in the TP53 promoter of Bovidae: phylogeny, novel mechanisms, and potential implications for cow milk persistency.BMC genomics · 2015Article
- Endogenous retroviruses in domestic animals.Current genomics · 2014Article
- RNA-seq analysis of equine conceptus transcripts during embryo fixation and capsule disappearance.PloS one · 2014Article
- A comparative analysis of mitochondrial ORFans: new clues on their origin and role in species with doubly uniparental inheritance of mitochondria.Genome biology and evolution · 2013Article
- Transcriptional regulation of two conceptus interferon tau genes expressed in Japanese black cattle during peri-implantation period.PloS one · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In evolution of mammals, some of essential genes for placental development are known to be of retroviral origin, as syncytin-1 derived from an envelope (env) gene of an endogenous retrovirus (ERV) aids in the cell fusion of placenta in humans. Although the placenta serves the same function in all placental mammals, env-derived genes responsible for trophoblast cell fusion and maternal immune tolerance differ among species and remain largely unidentified in the bovine species. To examine env-derived genes playing a role in the bovine placental development comprehensively, we determined the transcriptomic profiles of bovine conceptuses during three crucial windows of implantation periods using a high-throughput sequencer. The sequence reads were mapped into the bovine genome, in which ERV candidates were annotated using RetroTector(©) (7,624 and 1,542 for ERV-derived and env-derived genes, respectively). The mapped reads showed that approximately 18% (284 genes) of env-derived genes in the genome were expressed during placenta formation, and approximately 4% (63 genes) were detected for all days examined. We verified three env-derived genes that are expressed in trophoblast cells by polymerase chain reaction. Out of these three, the sequence of env-derived gene with the longest open reading frame (named BERV-P env) was found to show high expression levels in trophoblast cell lines and to be similar to those of syncytin-Car1 genes found in dogs and cats, despite their disparate origins. These results suggest that placentation depends on various retrovirus-derived genes that could have replaced endogenous predecessors during evolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.