ArticlePharmacoepidemiology and drug safety2013
Validation of an algorithm to estimate gestational age in electronic health plan databases.
Article in Pharmacoepidemiology and drug safety, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Birth and death notification via mobile devices: a mixed methods systematic review.The Cochrane database of systematic reviews · 2021Pooled it
- Enrollment and Retention in 34 United States Pregnancy Registries Contrasted with the Manufacturer's Capture of Spontaneous Reports for Exposed Pregnancies.Drug safety · 2018Pooled it
- Psychostimulant Continuation and Postpartum Mental Health in Pregnant People With Attention-Deficit/Hyperactivity Disorder.Obstetrics and gynecology · 2026Article
- Use of multiple sclerosis drugs among pregnant individuals with live-birth deliveries in the FDA's Sentinel Distributed Database.BMC pregnancy and childbirth · 2026Article
- Validation of pregnancy date estimation from outpatient electronic health record data.JAMIA open · 2026Article
- Machine Learning Estimation of Gestational Age at Delivery Using Linked Mother-Infant Electronic Health Records Across Two Health Systems.medRxiv : the preprint server for health sciences · 2026Article
- Diarrhoea events in offspring exposed to tumour necrosis factor inhibitors and rotavirus vaccine: a population-based cohort study.Rheumatology (Oxford, England) · 2026Article
- Serious Infections in Offspring Exposed to Tumor Necrosis Factor Inhibitors During Pregnancy: Comparison of Timing During Pregnancy and Placental Transfer Ability.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Sequential Safety Surveillance of RSVpreF Vaccination During Pregnancy Early in the Postapproval Period.JAMA network open · 2026Article
- Evaluation of gestational age by pregnancy outcomes and distribution of pregnancy-related codes in Korean claims data.Epidemiology and health · 2026Article
- Tumor Necrosis Factor Inhibitors and Risk of Serious Infections in Pregnant Women With Chronic Inflammatory Diseases.ACR open rheumatology · 2025Article
- Discontinuation of treatment for alcohol use disorder during pregnancy and postpartum in the United States.Alcohol, clinical & experimental research · 2025Article
- Development of a Pregnancy Cohort in Commercial Insurance Claims Data: Evaluation of Deliveries Identified From Inpatient Versus Outpatient Claims.Pharmacoepidemiology and drug safety · 2025Article
- Accounting for Twins and Other Multiple Births in Perinatal Studies of Live Births Conducted Using Healthcare Administration Data.Epidemiology (Cambridge, Mass.) · 2025Article
- Expanding the OMOP Common Data Model to Support Perinatal Research in Network Studies.Pharmacoepidemiology and drug safety · 2025Article
- Ambulatory care utilization in the first 24 months' postpartum by rurality and pregnancy-related conditions: A prospective cohort study from Maine.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2025Article
- Pregnancy episodes in All of Us: harnessing multi-source data for pregnancy-related research.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- Use of the Sentinel System to Examine Medical Product Use and Outcomes During Pregnancy.Drug safety · 2024Review
- Internal validation of gestational age estimation algorithms in health-care databases using pregnancies conceived through fertility procedures.American journal of epidemiology · 2024Article
- Timing of treatment for opioid use disorder among birthing people.Journal of substance use and addiction treatment · 2024Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 10 institutions in 1 country.
Funding
Abstract
purposeTo validate an algorithm that uses delivery date and diagnosis codes to define gestational age at birth in electronic health plan databases.
methodsUsing data from 225,384 live born deliveries to women aged 15-45 years in 2001-2007 within eight of the 11 health plans participating in the Medication Exposure in Pregnancy Risk Evaluation Program, we compared (1) the algorithm-derived gestational age versus the "gold-standard" gestational age obtained from the infant birth certificate file and (2) the prenatal exposure status of two antidepressants (fluoxetine and sertraline) and two antibiotics (amoxicillin and azithromycin) as determined by the algorithm-derived versus the gold-standard gestational age.
resultsThe mean algorithm-derived gestational age at birth was lower than the mean obtained from the birth certificate file among singleton deliveries (267.9 vs 273.5 days) but not among multiple-gestation deliveries (253.9 vs 252.6 days). The algorithm-derived prenatal exposure to the antidepressants had a sensitivity and a positive predictive value of ≥95%, and a specificity and a negative predictive value of almost 100%. Sensitivity and positive predictive value were both ≥90%, and specificity and negative predictive value were both >99% for the antibiotics.
conclusionsA gestational age algorithm based upon electronic health plan data correctly classified medication exposure status in most live born deliveries, but trimester-specific misclassification may be higher for drugs typically used for short durations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.