ReviewAge (Dordrecht, Netherlands)2013
Calorie restriction can reverse, as well as prevent, aging cardiomyopathy.
Review in Age (Dordrecht, Netherlands), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Nutrition in chronic heart failure patients: a systematic review.Heart failure reviews · 2020Pooled it
- The landscape of aging.Science China. Life sciences · 2022Review
- SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ.Cell reports · 2021Article
- Preconditioning with Short-term Dietary Restriction Attenuates Cardiac Oxidative Stress and Hypertrophy Induced by Chronic Pressure Overload.Nutrients · 2021Article
- Vascular Stiffness in Aging and Disease.Frontiers in physiology · 2021Review
- Healthful aging mediated by inhibition of oxidative stress.Ageing research reviews · 2020Review
- Mitophagy in cardiovascular homeostasis.Mechanisms of ageing and development · 2020Review
- Review
- Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice.The Journal of biological chemistry · 2020Article
- A Healthy Heart and a Healthy Brain: Looking at Mitophagy.Frontiers in cell and developmental biology · 2020Review
- Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles.Nature reviews. Cardiology · 2019Review
- Review
- Caloric Restriction Study Design Limitations in Rodent and Nonhuman Primate Studies.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Opposing effects on cardiac function by calorie restriction in different-aged mice.Aging cell · 2017Article
- Calorie restriction in rodents: Caveats to consider.Ageing research reviews · 2017Review
- Impact of Age, Caloric Restriction, and Influenza Infection on Mouse Gut Microbiome: An Exploratory Study of the Role of Age-Related Microbiome Changes on Influenza Responses.Frontiers in immunology · 2017Article
- Calorie restriction as an intervention in ageing.The Journal of physiology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Calorie restriction (CR) is the most widely studied intervention protecting from the adverse effects of aging. Almost all prior studies have examined the effects of CR initiated in young animals. Studies examining the effects of CR on development of aging cardiomyopathy found only partial prevention. The major goal of this study was to determine whether CR initiated after aging cardiomyopathy developed could reverse the cardiomyopathy. Aging cardiomyopathy in 2-year-old mice was characterized by reduced left ventricular (LV) function, cardiac hypertrophy, and increased cardiac apoptosis and fibrosis. When short-term (2 months) CR was initiated after aging cardiomyopathy developed in 20-month-old mice, the decrease in cardiac function, and increases in LV weight, myocardial fibrosis and apoptosis were reversed, such that the aging hearts in these mice were indistinguishable from those of young mice or mice where CR was initiated in young mice. If apoptosis was the mechanism for protecting against aging cardiomyopathy, then total myocyte numbers should have reverted to normal with CR, but did not. However, the alterations in cytoskeletal proteins, which contribute to aging cardiomyopathy, were no longer observed with CR. This is the first study to demonstrate complete prevention of aging cardiomyopathy by CR and, more importantly, that instituting this intervention even later in life can rapidly correct aging cardiomyopathy, which could have important therapeutic implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.