Evidence map›Paper›PMID 23334588›Full record

Trial reportCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2013

The effect of menthol on cigarette smoking behaviors, biomarkers and subjective responses.

Andrew A Strasser, Rebecca L Ashare, Madeline Kaufman, Kathy Z Tang, A Clementina Mesaros, Ian A Blair

2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01329263 nacompletednot on this map

Smoking Topography and Harm Exposure in Menthol Cigarettes

TypeinterventionalSponsorUniversity of PennsylvaniaRan2010 to 2011Enrolled87ConditionsCigarette Smoking ToxicityArmsMenthol to non-menthol
NCT04279483 nacompletednot on this mapstarted 2019, after this paper: background citation

Geo Smoking Study and Neural and Geospatial Examination of Smokers' Exposure to Retail Environments

TypeinterventionalSponsorAbramson Cancer Center at Penn MedicineRan2019 to 2024Enrolled343ConditionsSmoking, Tobacco, Smoking, Smoking, CigaretteArmsTobacco retailer, Non-tobacco retailer
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Pooled it
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  7. Effect on Tobacco Use and Subjective Measures of Including E-cigarettes in a Simulated Ban of Menthol in Combustible Cigarettes.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022
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  9. Effects on Smoking Behavior of Switching Menthol Smokers to Non-menthol Cigarettes.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2021
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  15. A Randomized Controlled Trial of Progressively Reduced Nicotine Content Cigarettes on Smoking Behaviors, Biomarkers of Exposure, and Subjective Ratings.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016
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  18. The Relative Reinforcing Value of Menthol Among Young Adult Cigarette Smokers: Results From a Behavioral Choice Task.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Andrew A StrasserCorresponding Author: Andrew A. Strasser, Center for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, USA. strasse3@mail.med.upenn.edu
Rebecca L Ashare
Madeline Kaufman
Kathy Z Tang
A Clementina Mesaros
Ian A Blair
University of Pennsylvania · US

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3M
Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3M
Neuroimaging Abstinence and Medication ResponseP50CA143187 · NCI · UNIVERSITY OF PENNSYLVANIA · PI AUDRAIN-MCGOVERN, JANET E · 2009 to 2013
$8.6M
Biomarkers of toxic response to low nicotine cigarette smokeR01CA130961 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BLAIR, IAN ALEXANDER, STRASSER, ANDREW A · 2009 to 2012
$2.3M
Smoking topography and harm exposure in a new PREPR01CA120594 · NCI · UNIVERSITY OF PENNSYLVANIA · PI STRASSER, ANDREW A · 2007 to 2011
$1.9M
NCI NIH HHS P30 CA016520NCI NIH HHS P50 CA143187NCI NIH HHS P50-CA143187NCI NIH HHS R01 CA120594NCI NIH HHS R01 CA130961NIEHS NIH HHS P30 ES013508NIEHS NIH HHS P30-ES013508PHS HHS R01-120594PHS HHS R01-120594-S1PHS HHS R01-130961
6 · The paper itself

Abstract

backgroundAs part of the Family Smoking Prevention and Tobacco Control Act, the U.S. Food and Drug Administration charged the Tobacco Products Scientific Advisory Committee with developing a report and recommendations about the effect of menthol in cigarettes on the public health. The purpose of this study was to examine smoking behaviors, biomarkers of exposure, and subjective responses when switching from a novel menthol cigarette to a non-menthol cigarette to isolate the effect of menthol and to approximate the effect a menthol ban might have on smokers.

methodsThirty-two adult smokers completed this 35-day randomized, open-label, laboratory study. After a 5-day baseline period, participants were randomized to the experimental group (n = 22) where they would smoke menthol Camel crush for 15 days followed by 15 days of non-menthol Camel crush, or the control group (n = 10) where they smoked their own brand cigarette across all periods. Participants attended study visits every 5 days and completed measures of smoking rate, smoking topography, biomarkers of exposure, and subjective responses.

resultsAlthough total puff volume tended to increase when the experimental group switched from menthol to non-menthol (P = 0.06), there were no corresponding increases in cigarette consumption or biomarkers of exposure (P > 0.1). Subjective ratings related to taste and smell decreased during the non-menthol period (P < 0.01), compared with the menthol.

conclusionsResults suggest menthol has minimal impact on smoking behaviors, biomarkers of exposure, and subjective ratings. IMPACT: When controlling for all other cigarette design features, menthol in cigarettes had minimal effect on outcome measures.

Indexed as

Health Behavior8-Hydroxy-2'-DeoxyguanosineAdultAgedBiomarkersChromatography, LiquidDeoxyguanosineEnvironmental ExposureFemaleFollow-Up StudiesHumansMaleMentholMiddle AgedPrognosisSmell8-Hydroxy-2'-DeoxyguanosineBiomarkersDeoxyguanosineMenthol

Identifiers

PMID23334588
PMCPMC3596436
OpenAlexW2114549745

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.