ArticleNature neuroscience2013
Grid cells require excitatory drive from the hippocampus.
Article in Nature neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 192 papers.
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Who cites it
192 citing papers in PubMed, 362 citations in OpenAlex.
- Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of aged APP knock-in mice.Cell reports · 2026Article
- A simple model of co-emergence of grid and place fields.bioRxiv : the preprint server for biology · 2026Article
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- Activation of the medial entorhinal cortex drives memory-guided navigation behavior.bioRxiv : the preprint server for biology · 2025Article
- Distinct brain regions map olfactory and visual spaces.bioRxiv : the preprint server for biology · 2025Article
- Speed modulations in grid cell information geometry.Nature communications · 2025Article
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- Hippocampus shapes entorhinal cortical output through a direct feedback circuit.Nature neuroscience · 2025Article
- Deep Learning-Emerged Grid Cells-Based Bio-Inspired Navigation in Robotics.Sensors (Basel, Switzerland) · 2025Review
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- Population coding and self-organized ring attractors in recurrent neural networks for continuous variable integration.Frontiers in network physiology · 2025Article
- A spatial transformation-based CAN model for information integration within grid cell modules.Cognitive neurodynamics · 2024Article
- Modeling the grid cell activity based on cognitive space transformation.Cognitive neurodynamics · 2024Article
- Article
- Improved Navigation Performance Through Memory Triggering Maps: AKN - journal of cartography and geographic information · 2024Review
- Modeling Grid Cell Distortions with a Grid Cell Calibration Mechanism.Cyborg and bionic systems (Washington, D.C.) · 2024Article
- Direct cortical inputs to hippocampal area CA1 transmit complementary signals for goal-directed navigation.Neuron · 2023Article
- Coherently remapping toroidal cells but not Grid cells are responsible for path integration in virtual agents.iScience · 2023Article
- Beyond Correlation: Optimal Transport Metrics For Characterizing Representational Stability and Remapping in Neurons Encoding Spatial Memory.bioRxiv : the preprint server for biology · 2023Article
- Ketamine evoked disruption of entorhinal and hippocampal spatial maps.Nature communications · 2023Article
132 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine how hippocampal backprojections influence spatially periodic firing in grid cells, we recorded neural activity in the medial entorhinal cortex (MEC) of rats after temporary inactivation of the hippocampus. We report two major changes in entorhinal grid cells. First, hippocampal inactivation gradually and selectively extinguished the grid pattern. Second, the same grid cells that lost their grid fields acquired substantial tuning to the direction of the rat's head. This transition in firing properties was contingent on a drop in the average firing rate of the grid cells and could be replicated by the removal of an external excitatory drive in an attractor network model in which grid structure emerges by velocity-dependent translation of activity across a network with inhibitory connections. These results point to excitatory drive from the hippocampus, and possibly other regions, as one prerequisite for the formation and translocation of grid patterns in the MEC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.