Evidence map›Paper›PMID 23334567›Full record

ArticleNanoscale2013

Virus-mimicking nano-constructs as a contrast agent for near infrared photoacoustic imaging.

Sharad Gupta, Muhammad R Chatni, Ayala L N Rao, Valentine I Vullev, Lihong V Wang, Bahman Anvari

Open access · greenAbstract read
In one paragraph

Article in Nanoscale, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 45 citations in OpenAlex.

  1. Effects of OACS applied bio materials · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Multifaceted aspects of charge transfer.Physical chemistry chemical physics : PCCP · 2020
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Contrast agents for photoacoustic and thermoacoustic imaging: a review.International journal of molecular sciences · 2014
    Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sharad GuptaDepartment of Bioengineering, University of California, Riverside, Riverside, CA 92521, USA.
Muhammad R Chatni
Ayala L N Rao
Valentine I Vullev
Lihong V Wang
Bahman Anvari
University of California, Riverside · USWashington University in St. Louis · US

Funding

Task Specific Project 3: Diffuse Optical TomographyU54CA136398 · NCI · WASHINGTON UNIVERSITY · PI GARBOW, JOEL RICHARD · 2008 to 2012
$6.0M
High-frequency multi-modality imaging:photoacousticR01EB000712 · NIBIB · WASHINGTON UNIVERSITY · PI WANG, LIHONG · 2002 to 2011
$4.2M
PHOTOACOUSTIC MICROSCOPY OF NEOVASCULARIZATION IN RENAL CANCER GROWTH AND THERAPYR01CA159959 · NCI · WASHINGTON UNIVERSITY · PI ARBEIT, JEFFREY MICHAEL · 2011 to 2015
$2.9M
Monitoring of Breast Neoadjuvant Therapy by Thermo- and Photo- Acoustic TomographR01CA134539 · NCI · WASHINGTON UNIVERSITY · PI MONSEES, BARBARA, WANG, LIHONG · 2009 to 2013
$2.9M
Photoacoustic endoscopy of Barretts esophagusR01CA157277 · NCI · WASHINGTON UNIVERSITY · PI MEYERS, BRYAN F, ZHOU, QIFA · 2010 to 2014
$2.7M
RECOVERY OF OPTICAL ABSORPTION COEFFICIENT IN QUANTITATIVE PHOTOACOUSTIC IMAGINGR01EB008085 · NIBIB · WASHINGTON UNIVERSITY · PI WANG, LIHONG · 2008 to 2011
$2.4M
NCI NIH HHS R01 CA134539NCI NIH HHS R01-CA134539NCI NIH HHS R01 CA157277NCI NIH HHS R01-CA157277NCI NIH HHS R01 CA159959NCI NIH HHS R01-CA159959NCI NIH HHS U54 CA136398NCI NIH HHS U54-CA136398NIBIB NIH HHS R01 EB000712NIBIB NIH HHS R01-EB000712NIBIB NIH HHS R01 EB008085NIBIB NIH HHS R01-EB008085
6 · The paper itself

Abstract

We report the first proof-of-principle demonstration of photoacoustic imaging using a contrast agent composed of a plant virus protein shell, which encapsulates indocyanine green (ICG), the only FDA-approved near infrared chromophore. These nano-constructs can provide higher photoacoustic signals than blood in tissue phantoms, and display superior photostability compared to non-encapsulated ICG. Our preliminary results suggest that the constructs do not elicit an acute immunogenic response in healthy mice.

Indexed as

AcousticsAdaptive ImmunityAnimalsBiomimetic MaterialsCell Line, TumorContrast MediaCytokinesHumansIndocyanine GreenInjections, IntravenousMiceMicroscopy, ConfocalNanostructuresTemperatureVirusesContrast MediaCytokinesIndocyanine Green

Identifiers

PMID23334567
PMCPMC3626106
OpenAlexW2119033930

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.