ReviewEnvironmental science and pollution research international2013
Glutathione and its dependent enzymes' modulatory responses to toxic metals and metalloids in fish--a review.
Review in Environmental science and pollution research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 229 citations in OpenAlex.
- Lysine and methionine supplementation ameliorates high inclusion of soybean meal inducing intestinal oxidative injury and digestive and antioxidant capacity decrease of yellow catfish.Fish physiology and biochemistry · 2018Trial
- Dietary Rosmarinic Acid Improved the Growth, Immunity and Antioxidation ofAnimals : an open access journal from MDPI · 2026Article
- Monitoring Hepatic Biomarker Responses in CagedJournal of xenobiotics · 2026Article
- Ellagic Acid Mitigates Lead (Pb)-Induced Toxicity inAntioxidants (Basel, Switzerland) · 2026Article
- Effects of Ammonia-Nitrogen-Reducing Biofilm on Stress Responses and Muscle Quality in Crucian Carp During Transportation.Foods (Basel, Switzerland) · 2026Article
- Multi-omics interrogation of herbivorous phenotype acquisition in hybrid culter under a 30% crude protein diet.BMC genomics · 2025Article
- Glutathione and astaxanthin: Both enhance antioxidant capacity and regulate lipid metabolism in Pacific white shrimp (Food chemistry. Molecular sciences · 2025Article
- Induced swimming reduced stress and modulated immune response and antioxidant status in juvenile rainbow trout (Oncorhynchus mykiss).Fish physiology and biochemistry · 2025Article
- Blood Orange (Antioxidants (Basel, Switzerland) · 2025Article
- Biopesticidal Efficacy and Safety of Azadirachtin: Broad-Spectrum Effects on Ectoparasites Infesting Goldfish,ACS omega · 2025Article
- Induced swimming in European seabass (Dicentrarchus labrax): effects on the stress response, immune, and antioxidant status.Fish physiology and biochemistry · 2025Article
- The Genomic Signature and Transcriptional Response of Metal Tolerance in Brown Trout Inhabiting Metal-Polluted Rivers.Molecular ecology · 2025Article
- Assessing the effects of cadmium on antioxidant enzymes and histological structures in rainbow trout liver and kidney.Scientific reports · 2024Article
- Growth, Nutrient Deposition, Plasma Metabolites, and Innate Immunity Are Associated with Feeding Rate in Juvenile Starry Flounder (Animals : an open access journal from MDPI · 2024Article
- Inclusion of Sorghum inAnimals : an open access journal from MDPI · 2024Article
- Effects of swimming activity and feed restriction on antioxidant and digestive enzymes in juvenile rainbow trout: Implications for nutritional and exercise strategies in aquaculture.Veterinary medicine and science · 2024Article
- Recent progress in practical applications of a potential carotenoid astaxanthin in aquaculture industry: a review.Fish physiology and biochemistry · 2024Review
- Oxidative stress, gene expression and histopathology of cultured gilthead sea bream (Sparus aurata) naturally co-infected with Ergasilus sieboldi and Vibrio alginolyticus.BMC veterinary research · 2023Article
- Biofloc Technology in Fish Aquaculture: A Review.Antioxidants (Basel, Switzerland) · 2023Review
- Effects on Bioaccumulation, Growth Performance, Hematological Parameters, Plasma Components, and Antioxidant Responses in Starry Flounder (Antioxidants (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toxic metals and metalloid are being rapidly added from multiple pathways to aquatic ecosystem and causing severe threats to inhabiting fauna including fish. Being common in all the type of aquatic ecosystems such as freshwater, marine and brackish water fish are the first to get prone to toxic metals and metalloids. In addition to a number of physiological/biochemical alterations, toxic metals and metalloids cause enhanced generation of varied reactive oxygen species (ROS) ultimately leading to a situation called oxidative stress. However, as an important component of antioxidant defence system in fish, the tripeptide glutathione (GSH) directly or indirectly regulates the scavenging of ROS and their reaction products. Additionally, several other GSH-associated enzymes such as GSH reductase (GR, EC 1.6.4.2), GSH peroxidase (EC 1.11.1.9), and GSH sulfotransferase (glutathione-S-transferase (GST), EC 2.5.1.18) cumulatively protect fish against ROS and their reaction products accrued anomalies under toxic metals and metalloids stress conditions. The current review highlights recent research findings on the modulation of GSH, its redox couple (reduced glutathione/oxidised glutathione), and other GSH-related enzymes (GR, glutathione peroxidase, GST) involved in the detoxification of harmful ROS and their reaction products in toxic metals and metalloids-exposed fish.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.