ReviewPediatric nephrology (Berlin, Germany)2013
Kidney-lung cross-talk and acute kidney injury.
Review in Pediatric nephrology (Berlin, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- Incidence and Outcomes of Acute Kidney Injury in COVID-19: A Systematic Review.Blood purification · 2022Pooled it
- Association of Fluid Balance With Short- and Long-term Respiratory Outcomes in Extremely Premature Neonates: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2022Trial
- Review
- Predictors and clinical outcomes of acute kidney injury after thoracic surgery: a retrospective cohort study.Journal of thoracic disease · 2026Article
- An online dynamic nomogram for predicting acute kidney injury after endovascular therapy in acute ischemic stroke.BMC nephrology · 2026Article
- Bacterial Pneumonia and Acute Kidney Injury: Association and Impact on Outcomes of Patients Hospitalized for Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD) in the United States.The open respiratory medicine journal · 2026Article
- Evaluating In-Hospital Arrhythmias in Critically Ill Acute Kidney Injury Patients: Predictive Models, Mortality Risks, and the Efficacy of Antiarrhythmic Drugs.Journal of clinical medicine · 2025Article
- Kidney complications in children with bronchopulmonary dysplasia.Pediatric research · 2025Article
- Risk analysis and mediation analysis of stress hyperglycemia ratio and all-cause mortality in patients with acute kidney injury.Diabetology & metabolic syndrome · 2025Article
- Caftaric acid attenuates kidney and remote organ damage induced by renal ischemia-reperfusion injury.Scientific reports · 2024Article
- Association of Acute Kidney Injury with Bronchopulmonary Dysplasia in Preterm Infants.Medeniyet medical journal · 2024Article
- Allograft function predicts mortality in kidney transplant recipients with severe COVID-19: a paradoxical risk factor.Frontiers in immunology · 2024Article
- Acute kidney injury decreases pulmonary vascular growth and alveolarization in neonatal rat pups.Pediatric research · 2023Article
- Protective Mechanism of Cordyceps sinensis Treatment on Acute Kidney Injury-Induced Acute Lung Injury through AMPK/mTOR Signaling Pathway.Chinese journal of integrative medicine · 2023Article
- The impact of hypoxia-inducible factors in the pathogenesis of kidney diseases: a link through cell metabolism.Kidney research and clinical practice · 2023Article
- Premature infants born <28 weeks with acute kidney injury have increased bronchopulmonary dysplasia rates.Pediatric research · 2023Article
- Positive fluid balance and diuretic therapy are associated with mechanical ventilation and mortality in preterm neonates in the first fourteen postnatal days.Pediatric nephrology (Berlin, Germany) · 2023Article
- Prevention of Chronic Morbidities in Extremely Premature Newborns with LISA-nCPAP Respiratory Therapy and Adjuvant Perinatal Strategies.Antioxidants (Basel, Switzerland) · 2023Review
- Neonatal fluid overload-ignorance is no longer bliss.Pediatric nephrology (Berlin, Germany) · 2023Review
- Development of a predictive nomogram for acute respiratory distress syndrome in patients with acute pancreatitis complicated with acute kidney injury.Renal failure · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
There is a growing appreciation for the role that acute kidney injury (AKI) plays in the propagation of critical illness. In children, AKI is not only an independent predictor of morbidity and mortality, but is also associated with especially negative outcomes when concurrent with acute lung injury (ALI). Experimental data provide evidence that kidney-lung crosstalk occurs and can be bidirectionally deleterious, although details of the precise molecular mechanisms involved in the AKI-ALI interaction remain incomplete. Clinically, ALI, and the subsequent clinical interventions used to stabilize gas exchange, carry consequences for the homeostasis of kidney function. Meanwhile, AKI negatively affects lung physiology significantly by altering the homeostasis of fluid balance, acid-base balance, and vascular tone. Experimental AKI research supports an "endocrine" role for the kidney, triggering a cascade of extra-renal inflammatory responses affecting lung homeostasis. In this review, we will discuss the pathophysiology of kidney-lung crosstalk, the multiple pathways by which AKI affects kidney-lung homeostasis, and discuss how these phenomena may be unique in critically ill children. Understanding how AKI may affect a "balance of communication" that exists between the kidneys and the lungs is requisite when managing critically ill children, in whom imbalance is the norm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.