Trial reportBone marrow transplantation2013
Citrulline and albumin as biomarkers for gastrointestinal mucositis in recipients of hematopoietic SCT.
Trial report in Bone marrow transplantation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- A Systematic Review of the Literature and Perspectives on the Role of Biomarkers in the Management of Malnutrition After Allogeneic Hematopoietic Stem Cell Transplantation.Frontiers in immunology · 2020Pooled it
- Enteral versus parenteral nutrition in auto-HCT: a randomized controlled trial on clinical outcomes and gut microbiome dynamics.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Trial
- Early post-transplant contrast-enhanced abdominopelvic CT scan predicts the risk of subsequent acute GvHD.Bone marrow transplantation · 2016Trial
- The incidence and risk factors of gastrointestinal dysfunction during enteral nutrition in mechanically ventilated critically ill patients.Nursing open · 2024Observational
- Mucositis-associated bloodstream infections in adult haematology patients with fever during neutropenia: risk factors and the impact of mucositis severity.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Observational
- Morphological Assessment and Biomarkers of Low-Grade, Chronic Intestinal Inflammation in Production Animals.Animals : an open access journal from MDPI · 2022Review
- Impact of mucositis on oral bioavailability and systemic exposure of ciprofloxacin Gram-negative infection prophylaxis in patients with haematological malignancies.The Journal of antimicrobial chemotherapy · 2022Article
- Camptothesome elicits immunogenic cell death to boost colorectal cancer immune checkpoint blockade.Journal of controlled release : official journal of the Controlled Release Society · 2022Article
- Prediction of outcomes after second-line treatment for acute graft-versus-host disease.Blood advances · 2022Article
- Article
- Citrulline, Biomarker of Enterocyte Functional Mass and Dietary Supplement. Metabolism, Transport, and Current Evidence for Clinical Use.Nutrients · 2021Review
- Translational model of melphalan-induced gut toxicity reveals drug-host-microbe interactions that drive tissue injury and fever.Cancer chemotherapy and pharmacology · 2021Article
- No effect of deleted in malignant brain tumors 1 deficiency on chemotherapy induced murine intestinal mucositis.Scientific reports · 2021Article
- Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Graft- versus -host disease.Einstein (Sao Paulo, Brazil) · 2020Article
- Pretransplant Serum Citrulline Predicts Acute Graft-versus-Host Disease.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2018Article
- Feeding strategies in pediatric cancer patients with gastrointestinal mucositis: a multicenter prospective observational study and international survey.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Observational
- Biomarkers and non-invasive tests for gastrointestinal mucositis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Review
- Protein calorie malnutrition, nutritional intervention and personalized cancer care.Oncotarget · 2017Review
- Serum citrulline as a biomarker of gastrointestinal function during hematopoietic cell transplantation in children.Journal of pediatric gastroenterology and nutrition · 2014Article
- Plasma citrulline as a biomarker for enterocyte integrity in pediatric blood and BMT.Bone marrow transplantation · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Gastrointestinal (GI) mucositis is a common side effect of intense chemotherapy to prepare patients for hematopoietic SCT. Measuring intestinal damage objectively remains difficult, and clinicians often rely on albumin levels as an indicator of GI mucositis, but citrulline might be a more specific marker, which has in the past been shown to correlate with clinical signs of GI mucositis. We evaluated the courses of albumin and citrulline following different conditioning regimens for SCT and studied their relatedness to the subsequent inflammatory response using C-reactive protein. Patterns of albumin and citrulline differed significantly between myeloablative and non-myeloablative conditioning regimens. After myeloablative regimens, decreasing citrulline levels preceded the occurrence of inflammation unlike albumin levels, which decreased thereafter. Albumin levels were greatly influenced by inflammation, confirming it to be a 'negative acute-phase protein', whereas citrulline levels were not. Citrulline appeared to be a better biomarker of GI mucositis than albumin. Measuring citrulline might prove useful in clinical decision making, in identifying GI mucositis, and it would also be of interest to see how it compares with other biomarkers in the setting of acute GI GVHD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.