Evidence map›Paper›PMID 23334244›Full record

ReviewNature reviews. Immunology2013

Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions.

Patrick J Brennan, Manfred Brigl, Michael B Brenner

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 499 papers.

0numbers the graph read from it
0cells of the map it votes in
499citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

499 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Priming of CD8Nature neuroscience · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. CD8bioRxiv : the preprint server for biology · 2026
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review

439 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Patrick J BrennanDepartment of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Manfred Brigl
Michael B Brenner

Funding

Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FLOREZ, JOSE CARLOS · 2000 to 2019
$31.4M
T LYMPOHOCYTE RECOGNITIONR01AI028973 · NIAID · DANA-FARBER CANCER INSTITUTE · PI BRENNER, MICHAEL B. · 1990 to 2014
$4.5M
CD1d-restricted T Cell Self-antigens and InfectionR01AI063428 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI BRENNER, MICHAEL B. · 2005 to 2015
$3.9M
T LYMPHOCYTE RECOGNITIONR37AI028973 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI BRENNER, MICHAEL B · 1995 to 2004
$1.7M
CD1d-restricted NKT cells in microbial infectionK08AI077795 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI BRIGL, MANFRED · 2008 to 2012
$782k
CD1d and NKT Cell Activation and Function in InfectionR56AI063428 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI BRENNER, MICHAEL B. · 2010 to 2010
$433k
NIAID NIH HHS AI028973NIAID NIH HHS AI063428NIAID NIH HHS AI077795NIAID NIH HHS K08 AI077795NIDDK NIH HHS DK057521
6 · The paper itself

Abstract

Invariant natural killer T (iNKT) cells exist in a 'poised effector' state, which enables them to rapidly produce cytokines following activation. Using a nearly monospecific T cell receptor, they recognize self and foreign lipid antigens presented by CD1d in a conserved manner, but their activation can catalyse a spectrum of polarized immune responses. In this Review, we discuss recent advances in our understanding of the innate-like mechanisms underlying iNKT cell activation and describe how lipid antigens, the inflammatory milieu and interactions with other immune cell subsets regulate the functions of iNKT cells in health and disease.

Indexed as

Immunity, InnateAnimalsCell CommunicationHumansLeukocytesLymphocyte ActivationNatural Killer T-CellsT-Lymphocyte Subsets

Identifiers

PMID23334244

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.