ReviewCardiovascular research2013
Combining wet and dry research: experience with model development for cardiac mechano-electric structure-function studies.
Review in Cardiovascular research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed.
- Mathematical model of the zebrafish ventricular cardiomyocyte action potential and calcium transient.The Journal of physiology · 2026Article
- Models of the human heart for biomedical research: Opportunities and challenges.Physiological reports · 2026Review
- From AI-AssistedPharmaceuticals (Basel, Switzerland) · 2025Review
- Embedded Computational Heart Model for External Ventricular Assist Device Investigations.Cardiovascular engineering and technology · 2022Article
- From Mice to Mainframes: Experimental Models for Investigation of the Intracardiac Nervous System.Journal of cardiovascular development and disease · 2021Review
- What keeps us ticking? Sinoatrial node mechano-sensitivity: the grandfather clock of cardiac rhythm.Biophysical reviews · 2021Review
- Application of physics-based flow models in cardiovascular medicine: Current practices and challenges.Biophysics reviews · 2021Review
- Neurohumoral Control of Sinoatrial Node Activity and Heart Rate: Insight From Experimental Models and Findings From Humans.Frontiers in physiology · 2020Review
- Sinoatrial Node Structure, Mechanics, Electrophysiology and the Chronotropic Response to Stretch in Rabbit and Mouse.Frontiers in physiology · 2020Article
- Simulated Performance of the Cleveland Clinic Continuous-Flow Total Artificial Heart Using the Virtual Mock Loop.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2019Article
- Editorial: The Role of Calcium Handling in Heart Failure and Heart Failure Associated Arrhythmias.Frontiers in physiology · 2019Article
- Cardiac ischemia-insights from computational models.Herzschrittmachertherapie & Elektrophysiologie · 2018Review
- Mechanically Induced Ectopy via Stretch-Activated Cation-Nonselective Channels Is Caused by Local Tissue Deformation and Results in Ventricular Fibrillation if Triggered on the Repolarization Wave Edge (Commotio Cordis).Circulation. Arrhythmia and electrophysiology · 2017Article
- Comparing maximum rate and sustainability of pacing by mechanical vs. electrical stimulation in the Langendorff-perfused rabbit heart.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2016Article
- Rabbit models of cardiac mechano-electric and mechano-mechanical coupling.Progress in biophysics and molecular biology · 2016Review
- Rabbit-specific computational modelling of ventricular cell electrophysiology: Using populations of models to explore variability in the response to ischemia.Progress in biophysics and molecular biology · 2016Article
- Fibroblast-myocyte coupling in the heart: Potential relevance for therapeutic interventions.Journal of molecular and cellular cardiology · 2016Review
- Cardiac Mechano-Gated Ion Channels and Arrhythmias.Circulation research · 2016Review
- Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm.Progress in biophysics and molecular biology · 2016Article
- Mechano-electric heterogeneity of the myocardium as a paradigm of its function.Progress in biophysics and molecular biology · 2016Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Since the development of the first mathematical cardiac cell model 50 years ago, computational modelling has become an increasingly powerful tool for the analysis of data and for the integration of information related to complex cardiac behaviour. Current models build on decades of iteration between experiment and theory, representing a collective understanding of cardiac function. All models, whether computational, experimental, or conceptual, are simplified representations of reality and, like tools in a toolbox, suitable for specific applications. Their range of applicability can be explored (and expanded) by iterative combination of 'wet' and 'dry' investigation, where experimental or clinical data are used to first build and then validate computational models (allowing integration of previous findings, quantitative assessment of conceptual models, and projection across relevant spatial and temporal scales), while computational simulations are utilized for plausibility assessment, hypotheses-generation, and prediction (thereby defining further experimental research targets). When implemented effectively, this combined wet/dry research approach can support the development of a more complete and cohesive understanding of integrated biological function. This review illustrates the utility of such an approach, based on recent examples of multi-scale studies of cardiac structure and mechano-electric function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.