ArticleVirulence2013
A novel bioluminescence mouse model for monitoring oropharyngeal candidiasis in mice.
Article in Virulence, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Using Bioluminescence to Image Candida glabrata Urinary Tract Infections in Mice.Methods in molecular biology (Clifton, N.J.) · 2023Article
- InvestigatingJournal of fungi (Basel, Switzerland) · 2021Article
- Fluorescent toys 'n' tools lighting the way in fungal research.FEMS microbiology reviews · 2021Article
- Let's shine a light on fungal infections: A noninvasive imaging toolbox.PLoS pathogens · 2020Review
- Oral Candidiasis: A Disease of Opportunity.Journal of fungi (Basel, Switzerland) · 2020Review
- Sensitive bioluminescence imaging of fungal dissemination to the brain in mouse models of cryptococcosis.Disease models & mechanisms · 2019Article
- A Bright Future for Fluorescence Imaging of Fungi in Living Hosts.Journal of fungi (Basel, Switzerland) · 2019Review
- Monitoring of Fluconazole and Caspofungin Activity againstAntimicrobial agents and chemotherapy · 2019Article
- Article
- Methodologies forMicrobial cell (Graz, Austria) · 2018Review
- In-vivo monitoring of infectious diseases in living animals using bioluminescence imaging.Virulence · 2018Review
- Red-Shifted Firefly Luciferase Optimized forFrontiers in microbiology · 2017Article
- Plasticity of Candida albicans Biofilms.Microbiology and molecular biology reviews : MMBR · 2016Review
- Combination of Estrogen and Immunosuppressive Agents to Establish a Mouse Model of Candidiasis with Concurrent Oral and Vaginal Mucosal Infection.Mycopathologia · 2016Article
- In Vitro and In Vivo Antifungal Activity of Lichochalcone-A against Candida albicans Biofilms.PloS one · 2016Article
- Candida albicans biofilm development on medically-relevant foreign bodies in a mouse subcutaneous model followed by bioluminescence imaging.Journal of visualized experiments : JoVE · 2015Article
- Lightning up the worm: How to probe fungal virulence in an alternative mini-host by bioluminescence.Virulence · 2015Article
- Candida albicans Biofilms and Human Disease.Annual review of microbiology · 2015Review
- Overview of vertebrate animal models of fungal infection.Journal of immunological methods · 2014Review
- Illuminating fungal infections with bioluminescence.PLoS pathogens · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oropharyngeal Candida albicans (C. albicans) infection usually occurs in patients with altered cell-mediated immune response. Many animal models have been developed for studying the pathogenesis of disease. Here we describe a new model for real-time monitoring of oral candidiasis. Mice were rendered susceptible to oral candidiasis by injection with cortisone acetate. Oral infection was performed by placing a swab saturated with genetically engineered bioluminescent strain of C. albicans sublingually. An in vivo imaging technique, exploiting stably trasformed C. albicans that costitutively express luciferase, was adopted. This novel longitudinal study represents a powerful tool to: (1) test real-time progression of infection, (2) identify the target site of C. albicans in specific organs, (3) evaluate the efficacy of antifungal therapies and (4) explore the spread of C. albicans from the local to systemic compartment in a new way.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.