ArticleDevelopmental biology2013
Lack of tailless leads to an increase in expression variability in Drosophila embryos.
Article in Developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Global repression by tailless during segmentation.Developmental biology · 2024Article
- Functional analysis of the Drosophila eve locus in response to non-canonical combinations of gap gene expression levels.Developmental cell · 2023Article
- Article
- Molecular Characterization and Expression Profiling of Nuclear Receptor Gene Families in Oriental Fruit Fly,Insects · 2020Article
- Article
- The developmental genetics of biological robustness.Annals of botany · 2016Review
- Quantitatively predictable control of Drosophila transcriptional enhancers in vivo with engineered transcription factors.Nature genetics · 2016Article
- Pervasive robustness in biological systems.Nature reviews. Genetics · 2015Review
- A gene expression atlas of a bicoid-depleted Drosophila embryo reveals early canalization of cell fate.Development (Cambridge, England) · 2015Article
- Global sensitivity analysis of a dynamic model for gene expression in Drosophila embryos.PeerJ · 2015Article
- High-resolution gene expression data from blastoderm embryos of the scuttle fly Megaselia abdita.Scientific data · 2015Article
- Cryptic genetic variation can make "irreducible complexity" a common mode of adaptation in sexual populations.Evolution; international journal of organic evolution · 2014Article
- Article
- Article
- Article
- Reverse-engineering post-transcriptional regulation of gap genes in Drosophila melanogaster.PLoS computational biology · 2013Article
- Q&A: Evolutionary capacitance.BMC biology · 2013Article
- Mechanistic explanations for restricted evolutionary paths that emerge from gene regulatory networks.PloS one · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
Developmental processes are robust, or canalised: dynamic patterns of gene expression across space and time are regulated reliably and precisely in the presence of genetic and environmental perturbations. It remains unclear whether canalisation relies on specific regulatory factors (such as heat-shock proteins), or whether it is based on more general redundancy and distributed robustness at the network level. The latter explanation implies that mutations in many regulatory factors should exhibit loss of canalisation. Here, we present a quantitative characterisation of segmentation gene expression patterns in mutants of the terminal gap gene tailless (tll) in Drosophila melanogaster. Our analysis provides new insights into the dynamic mechanisms underlying gap gene regulation, and reveals significantly increased variability of gene expression in the mutant compared to the wild-type background. We show that both position and timing of posterior segmentation gene expression domains vary strongly from embryo-to-embryo in tll mutants. This variability must be caused by a vulnerability in the regulatory system which is hidden or buffered in the wild-type, but becomes uncovered by the deletion of tll. Our analysis provides evidence that loss of canalisation in mutants could be more widespread than previously thought.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.