ReviewCurrent opinion in chemical biology2013
The importance of water exchange rates in the design of responsive agents for MRI.
Review in Current opinion in chemical biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 114 citations in OpenAlex.
- Unmasking Early Hepatorenal Fibrosis in Polycystic Kidney Disease Using Noninvasive Precision Molecular MRI of Collagen.bioRxiv : the preprint server for biology · 2026Article
- Molecular Imaging of In Vivo Zinc Distribution Using Nuclear and Magnetic Resonance Imaging.Chemical & biomedical imaging · 2026Review
- Gadolinium-Based Contrast Agents (GBCAs) for MRI: A Benefit-Risk Balance Analysis from a Chemical, Biomedical, and Environmental Point of View.Global challenges (Hoboken, NJ) · 2025Review
- Quantitative in Vivo Molecular MRI.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- α-Aryl substituted GdDOTA derivatives, the perfect contrast agents for MRI?Chemical communications (Cambridge, England) · 2024Article
- Gold nanoparticles conjugated with epidermal growth factor and gadolinium for precision delivery of contrast agents in magnetic resonance imaging.Radiological physics and technology · 2024Article
- Endeavor toward Redox-Responsive Transition Metal Contrast Agents Based on the Cross-Bridge Cyclam Platform.Inorganic chemistry · 2024Article
- Analysis of Stable Chelate-free Gadolinium Loaded Titanium Dioxide Nanoparticles for MRI-Guided Radionuclide Stimulated Cancer Treatment.Current analytical chemistry · 2022Article
- Repurposing ICG enables MR/PA imaging signal amplification and iron depletion for iron-overload disorders.Science advances · 2021Article
- Iron oxide nanoparticles for immune cell labeling and cancer immunotherapy.Nanoscale horizons · 2021Review
- A DNA-Based MRI Contrast Agent for Quantitative pH Measurement.ACS sensors · 2021Article
- Rational Design of High-Relaxivity EuChemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Supramolecular adducts between macrocyclic Gd(iii) complexes and polyaromatic systems: a route to enhance the relaxivity through the formation of hydrophobic interactions.Chemical science · 2020Article
- Dynamic Quantum Sensing of Paramagnetic Species Using Nitrogen-Vacancy Centers in Diamond.ACS sensors · 2020Article
- Isomeric Co(ii) paraCEST agents as pH responsive MRI probes.Dalton transactions (Cambridge, England : 2003) · 2020Article
- A Ln(III)-3-hydroxypyridine pH responsive probe optimized by DFT.RSC advances · 2020Article
- Single- and Multi-Arm Gadolinium MRI Contrast Agents for Targeted Imaging of Glioblastoma.International journal of nanomedicine · 2020Article
- Magnetic Nanoparticles Supporting Bio-responsiveMaterials (Basel, Switzerland) · 2019Review
- Imaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH.Cancer metastasis reviews · 2019Review
- Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.Chemical reviews · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The rate of water exchange in lanthanide complexes is often overlooked as an important parameter in the design of responsive MR imaging agents. Most often, the number of inner-sphere water coordination sites or the rotational mobility of the complex is considered as the central theme while water exchange is either assumed to be "fast enough" or entirely ignored. On the contrary, relaxation and shift theories predict that water exchange rates may indeed be the key parameter one should consider in any new molecular design. In this short review, the impact of water exchange rates on three classes of lanthanide-based MRI contrast agents, T₁-based relaxation agents, T₂ exchange line-broadening agents and chemical exchange saturation transfer (CEST) agents, is illustrated and discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.