ArticleBrain research2013
An update on the cognitive impact of clinically-used hormone therapies in the female rat: models, mazes, and mechanisms.
Article in Brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Distinct cognitive effects of estrogen and progesterone in menopausal women.Psychoneuroendocrinology · 2015Trial
- The intersection between menopause and depression: overview of research using animal models.Frontiers in psychiatry · 2024Review
- From Menopause to Neurodegeneration-Molecular Basis and Potential Therapy.International journal of molecular sciences · 2021Review
- Effects of Female Sex Steroids Administration on Pathophysiologic Mechanisms in Traumatic Brain Injury.Translational stroke research · 2018Review
- Estradiol Protects White Matter of Male C57BL6J Mice against Experimental Chronic Cerebral Hypoperfusion.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2018Article
- Estrogens as neuroprotectants: Estrogenic actions in the context of cognitive aging and brain injury.Progress in neurobiology · 2017Review
- Sex and post-menopause hormone therapy effects on hippocampal volume and verbal memory.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2017Article
- Effect of Ovarian Hormone Therapy on Cognition in the Aged Female Rhesus Macaque.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Benefits of Hormone Therapy Estrogens Depend on Estrogen Type: 17β-Estradiol and Conjugated Equine Estrogens Have Differential Effects on Cognitive, Anxiety-Like, and Depressive-Like Behaviors and Increase Tryptophan Hydroxylase-2 mRNA Levels in Dorsal Raphe Nucleus Subregions.Frontiers in neuroscience · 2016Article
- Sex steroid hormones matter for learning and memory: estrogenic regulation of hippocampal function in male and female rodents.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Review
- Trajectories and phenotypes with estrogen exposures across the lifespan: What does Goldilocks have to do with it?Hormones and behavior · 2015Article
- Estrogens and cognition: Friends or foes?: An evaluation of the opposing effects of estrogens on learning and memory.Hormones and behavior · 2015Review
- Article
- Understanding the cognitive impact of the contraceptive estrogen Ethinyl Estradiol: tonic and cyclic administration impairs memory, and performance correlates with basal forebrain cholinergic system integrity.Psychoneuroendocrinology · 2015Article
- Estradiol replacement extends the window of opportunity for hippocampal function.Neurobiology of aging · 2014Article
- Estradiol and cognitive function: past, present and future.Hormones and behavior · 2014Review
- Premature menopause and risk of neurological disease: basic mechanisms and clinical implications.Molecular and cellular endocrinology · 2014Review
- Use of an eight-arm radial water maze to assess working and reference memory following neonatal brain injury.Journal of visualized experiments : JoVE · 2013Article
- The effects of dietary treatment with S-equol on learning and memory processes in middle-aged ovariectomized rats.Neurotoxicology and teratologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
In women, ovarian hormone loss associated with menopause has been related to cognitive decline. Hormone therapy (HT) may ameliorate some of these changes. Understanding the cognitive impact of female steroids, including estrogens, progestogens, and androgens, is key to discovering treatments that promote brain health in women. The preclinical literature has presented elegant and methodical experiments allowing a better understanding of parameters driving the cognitive consequences of ovarian hormone loss and HT. Animal models have been a valuable tool in this regard, and will be vital to future discoveries. Here, we provide an update on the literature evaluating the impact of female steroid hormones on cognition, and the putative mechanisms mediating these effects. We focus on preclinical work that was done with an eye toward clinical realities. Parameters that govern the cognitive efficacy of HT, from what we know thus far, include but are not limited to: type, dose, duration, and route of HT, age at HT initiation, timing of HT relative to ovarian hormone loss, memory type examined, menopause history, and hormone receptor status. Researchers have identified intricate relationships between some of these factors by studying their individual effects on cognition. As of late, there is increased focus on studying interactions between these variables as well as multiple hormone types when administered concomitantly. This is key to translating preclinical data to the clinic, wherein women typically have concurrent exposure to endogenous ovarian hormones as well as exogenous combination HTs, which include both estrogens and progestins. Gains in understanding the parameters of HT effects on cognition provide exciting novel avenues that can inform clinical treatments, eventually expanding the window of opportunity to optimally enhance cognition and brain health in aging women. This article is part of a Special Issue entitled Hormone Therapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.