Evidence map›Paper›PMID 23333445›Full record

ArticleJournal of hepatology2013

Differential effects of donor and recipient IL28B and DDX58 SNPs on severity of HCV after liver transplantation.

Scott W Biggins, James Trotter, Jane Gralla, James R Burton, Kiran M Bambha, Jennifer Dodge, Megan Brocato, Linling Cheng, Matt McQueen, Lisa Forman and 6 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of hepatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Challenging hepatitis C-infected liver transplant patients.Hepatic medicine : evidence and research · 2016
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Emerging concepts in immunity to hepatitis C virus infection.The Journal of clinical investigation · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Scott W BigginsUniversity of Colorado Denver, Division of Gastroenterology and Hepatology, Aurora, CO 80045, United States. Scott.Biggins@ucdenver.edu
James Trotter
Jane Gralla
James R Burton
Kiran M Bambha
Jennifer Dodge
Megan Brocato
Linling Cheng
Matt McQueen
Lisa Forman
Michael Chang
Igal Kam
Gregory Everson
Richard A Spritz
Goran Klintmalm
Hugo R Rosen

Funding

Social Demographic Moderation of Genome Wide Associations for Body Mass IndexR01HD060726 · NICHD · UNIVERSITY OF COLORADO · PI BOARDMAN, JASON D, MCQUEEN, MATTHEW B · 2010 to 2014
$2.7M
Midcareer Investigator Award in Patient-Oriented Research (K24)K24AI083742 · NIAID · UNIVERSITY OF COLORADO DENVER · PI ROSEN, HUGO RAMON · 2009 to 2013
$888k
Bias in Retransplantation Survival Models: Selection Criteria and Hepatitis CK08DK076565 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BIGGINS, SCOTT W · 2007 to 2011
$610k
NIAID NIH HHS K24 AI083742NIAID NIH HHS K24AI083742NICHD NIH HHS R01 HD060726NIDDK NIH HHS DK076565NIDDK NIH HHS K08 DK076565
6 · The paper itself

Abstract

BACKGROUND &

aimsIL28B single nucleotide polymorphisms are strongly associated with spontaneous HCV clearance and treatment response in non-transplant populations. A DDX58 single nucleotide polymorphism is associated with the antiviral response of innate lymphocytes. We aimed at evaluating the associations of donor and recipient IL28B (rs12979860 and rs8099917) and DDX58 (rs10813831) genotypes with severity of HCV recurrence after liver transplantation.

methodsIn a case-control study of 523 liver transplantation recipients with HCV, we matched severe with mild recurrent HCV based on 2-year clinical and histologic follow-up. A total of 440 liver transplantation recipients (severe, n=235; mild, n=205) with recipient DNA and 225 (severe, n=123; mild, n=102) with both recipient and donor DNA were analyzed.

resultsIL28B [rs12979860, non-CC (vs. CC) and rs8099917, non-TT (vs. TT)] in the recipient-only analysis had higher risk of severe recurrent HCV [OR 1.57 and 1.58, p<0.05]. However, for the 225 with donor and recipient DNA, IL28B rs12979860 CC (vs. non-CC) and rs8099917 TT (vs. non-TT) and DDX58 rs10813831 non-GG (vs. GG) were associated with more (not less) severe recurrent HCV. The greatest risk of severe recurrent HCV was for rs12979860 CC donors in non-CC recipients (OR 7.02, p <0.001, vs. non-CC donor/recipient) and for rs8099917 TT donors in non-TT recipients (OR 5.78, p=0.001, vs. non-TT donor/recipient). These associations persisted after controlling for donor age, donor race, and donor risk index.

conclusionsIL28B and DDX58 single nucleotide polymorphisms that are favorable when present in the non-transplant setting or in the recipient are unfavorable when present in a donor liver graft.

Indexed as

Liver TransplantationSeverity of Illness IndexTissue DonorsTransplantationAdultBiopsyCase-Control StudiesDEAD Box Protein 58DEAD-box RNA HelicasesFemaleFollow-Up StudiesGenetic Predisposition to DiseaseGenotypeHepatitis CHumansInterferon LambdaDEAD Box Protein 58DEAD-box RNA HelicasesInterferon Lambdainterferon-lambda, humanInterferonsInterleukinsReceptors, ImmunologicRIGI protein, human

Identifiers

PMID23333445
PMCPMC3878646

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.