Trial reportInternational journal of cardiology2013
Risk factors for incident atrial fibrillation with and without left atrial enlargement in women.
Trial report in International journal of cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Atrial fibrillation and human immunodeficiency virus type-1 infection: a systematic review. Implications for anticoagulant and antiarrhythmic therapy.British journal of clinical pharmacology · 2019Pooled it
- Body mass index, abdominal fatness, fat mass and the risk of atrial fibrillation: a systematic review and dose-response meta-analysis of prospective studies.European journal of epidemiology · 2017Pooled it
- Risk factors for atrial fibrillation in patients with normal versus dilated left atrium (from the Atherosclerosis Risk in Communities Study).The American journal of cardiology · 2014Trial
- Brazilian Atrial Fibrillation Guidelines - 2025.Arquivos brasileiros de cardiologia · 2025Article
- The Role of Galectin-3 Levels for Predicting Paroxysmal Atrial Fibrillation in Patients with Embolic Stroke of Undetermined Source.Journal of clinical medicine · 2024Article
- Association between Obesity and Atrial Function in Patients with Non-Valvular Atrial Fibrillation: An Echocardiographic Study.Journal of clinical medicine · 2024Article
- QTc interval prolongation and risk of atrial fibrillation recurrence: a meta-analysis and observational cohort study.Frontiers in cardiovascular medicine · 2024Article
- NADPH Oxidases and Oxidative Stress in the Pathogenesis of Atrial Fibrillation.Antioxidants (Basel, Switzerland) · 2023Review
- Stimulant Drugs of Abuse and Cardiac Arrhythmias.Circulation. Arrhythmia and electrophysiology · 2022Review
- Article
- Change in Atrial Fibrillation Burden over Time in Patients with Nonpermanent Atrial Fibrillation.Cardiology research and practice · 2020Article
- Sex differences in cardiometabolic disorders.Nature medicine · 2019Review
- Left Atrial Strain for Predicting Atrial Fibrillation Onset in Hypertensive Patients.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2019Article
- Aerobic Interval Training Prevents Age-Dependent Vulnerability to Atrial Fibrillation in Rodents.Frontiers in physiology · 2018Article
- Gender, race, age, and regional differences in the association of pulse pressure with atrial fibrillation: the Reasons for Geographic and Racial Differences in Stroke study.Journal of the American Society of Hypertension : JASH · 2016Article
- Article
- Risk factors for atrial fibrillation in type 2 diabetes: report from the Swedish National Diabetes Register (NDR).Diabetologia · 2015Article
- Sex differences in stroke prevention in atrial fibrillation in French primary care. Results of the AFIGP (Atrial Fibrillation In General Practice) database.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Article
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
backgroundLeft atrial (LA) enlargement facilitates induction and/or maintenance of atrial fibrillation (AF). However, little is known about risk factors for AF with normal LA size.
methodsWe prospectively followed 34713 initially healthy women for incident AF. Information on echocardiographic LA size at first AF diagnosis was abstracted from medical charts during AF confirmation. LA enlargement was defined as LA diameter >40 mm. Using a competing risk approach, we constructed Cox proportional-hazards models to calculate hazard ratios (HR) and 95% confidence intervals (CI) of risk factors for incident AF with and without LA enlargement, respectively.
resultsAmong 796 women with incident AF and available LA size, 328 (41%) had LA enlargement. In multivariable competing risk models, the relationship between age and incident AF was stronger in those with (HR 1.12, 95% CI 1.10-1.14) versus without (HR 1.08, 95% CI 1.06-1.09) LA enlargement (p for difference <0.0001). Body weight was associated with AF only in the presence of LA enlargement (HR per 10 kg 1.34, 95% CI 1.26-1.43; versus 1.07, 95% CI 0.998-1.14, p for difference<0.0001). Hypertension and height were significantly associated with AF both in the presence (HR 1.99, 95% CI 1.49-2.65; and HR per 10 cm 1.36, 95% CI 1.13-1.63) and absence (1.55, 1.25-1.92 and 1.29, 1.10-1.50) of LA enlargement (p for difference 0.17 and 0.66, respectively).
conclusionsThese data suggest that LA enlargement explains much of the increased AF risk associated with obesity and age. In contrast, height and hypertension appear to also influence AF risk through other mechanisms besides LA enlargement.
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