ReviewTrends in neurosciences2013
Nothing tastes as good as skinny feels: the neurobiology of anorexia nervosa.
Review in Trends in neurosciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 241 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
241 citing papers in PubMed, 12 syntheses or guidelines pooled it, 511 citations in OpenAlex.
- Efficacy of transcranial magnetic stimulation in anorexia nervosa: a systematic review and meta-analysis.Eating and weight disorders : EWD · 2025Pooled it
- The Neural Correlates of Body Image Processing in Anorexia Nervosa and Bulimia Nervosa: An Activation Likelihood Estimation Meta-Analysis of fMRI Studies.International journal of environmental research and public health · 2025Pooled it
- Altered value-based decision-making in anorexia nervosa: A systematic review.Neuroscience and biobehavioral reviews · 2024Pooled it
- The cerebellum plays more than one role in the dysregulation of appetite: Review of structural evidence from typical and eating disorder populations.Brain and behavior · 2023Pooled it
- Brain-based gene expression of putative risk genes for anorexia nervosa.Molecular psychiatry · 2023Pooled it
- Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group.Biological psychiatry · 2022Pooled it
- Neural correlates associated with processing food stimuli in anorexia nervosa and bulimia nervosa: an activation likelihood estimation meta-analysis of fMRI studies.Eating and weight disorders : EWD · 2022Pooled it
- Moving towards specificity: A systematic review of cue features associated with reward and punishment in anorexia nervosa.Clinical psychology review · 2020Pooled it
- White Matter Abnormalities in Anorexia Nervosa: Psychoradiologic Evidence From Meta-Analysis of Diffusion Tensor Imaging Studies Using Tract Based Spatial Statistics.Frontiers in neuroscience · 2020Pooled it
- Altered thalamo–cortical and occipital–parietal– temporal–frontal white matter connections in patients with anorexia and bulimia nervosa: a systematic review of diffusion tensor imaging studiesJournal of psychiatry & neuroscience : JPN · 2019Pooled it
- Taste sensitivity in anorexia nervosa: A systematic review.The International journal of eating disorders · 2018Pooled it
- A systematic review of reviews of neurocognitive functioning in eating disorders: The state-of-the-literature and future directions.The International journal of eating disorders · 2018Pooled it
- No effects of acute tryptophan depletion on anxiety or mood in weight-recovered female patients with anorexia nervosa.European archives of psychiatry and clinical neuroscience · 2023Trial
- Neuroimaging of hypothalamic mechanisms related to glucose metabolism in anorexia nervosa and obesity.The Journal of clinical investigation · 2020Trial
- Stress induced hyperphagia iniScience · 2026Article
- Brain Connectivity and Machine Learning Approaches to assess the underlying neurobiology and prediction accuracy of anorexia nervosa: A replication study.Psychiatry research. Neuroimaging · 2026Article
- Post-Meal Activity and Eating Disorder Behaviors: An Ecological Momentary Assessment (EMA) Study.The International journal of eating disorders · 2026Article
- Long-Term Recovery Following Adolescent Anorexia Nervosa: A Mixed-Methods Follow-Up Study.Nutrients · 2026Article
- Neural circuits regulating activity-based anorexia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Link Between Anhedonia, Reward Dysfunction, and Eating Behavior Across Mental and Physical Health Conditions: A Narrative Review.Nutrients · 2026Review
181 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Individuals with anorexia nervosa (AN) engage in relentless restrictive eating and often become severely emaciated. Because there are no proven treatments, AN has high rates of relapse, chronicity, and death. Those with AN tend to have childhood temperament and personality traits, such as anxiety, obsessions, and perfectionism, which may reflect neurobiological risk factors for developing AN. Restricted eating may be a means of reducing negative mood caused by skewed interactions between serotonin aversive or inhibitory and dopamine reward systems. Brain imaging studies suggest that altered eating is a consequence of dysregulated reward and/or awareness of homeostatic needs, perhaps related to enhanced executive ability to inhibit incentive motivational drives. An understanding of the neurobiology of this disorder is likely to be important for developing more effective treatments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.