ArticleProceedings of the National Academy of Sciences of the United States of America1990
Human interleukin 2 receptor beta-chain gene: chromosomal localization and identification of 5' regulatory sequences.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Bcl-3 expression promotes cell survival following interleukin-4 deprivation and is controlled by AP1 and AP1-like transcription factors.Molecular and cellular biology · 2000Article
- Genetic mapping of the interleukin 1 receptor alpha and beta chain genes in the mouse.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
- Article
- Characterization of the human interleukin-2 receptor beta-chain gene promoter: regulation of promoter activity by ets gene products.Molecular and cellular biology · 1993Article
- Identification and characterization of new human medium reiteration frequency repeats.Nucleic acids research · 1993Article
- Requirements for the induction of the interleukin-2 receptor complex in a human pre-T-cell line.Immunology · 1993Article
- The IL-2 receptor beta chain gene (Il-2rb) is closely linked to the Pdgfb locus on mouse chromosome 15.Immunogenetics · 1993Article
- A brefeldin A-like phenotype is induced by the overexpression of a human ERD-2-like protein, ELP-1.Cell · 1992Article
- Interleukin (IL)-2 and IL-3 induce distinct but overlapping responses in murine IL-3-dependent 32D cells transduced with human IL-2 receptor beta chain: involvement of tyrosine kinase(s) other than p56lck.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Dinucleotide repeat polymorphism in the IL-2R beta gene.Nucleic acids research · 1991Article
- Oligonucleotide inhibition of IL2R alpha mRNA transcription by promoter region collinear triplex formation in lymphocytes.Nucleic acids research · 1991Article
- Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin 2 (IL-2) binds to and stimulates activated T cells through high-affinity IL-2 receptors (IL-2Rs). Such receptors represent a complex consisting of at least two proteins, the 55-kDa IL-2R alpha chain and the 70-kDa IL-2R beta chain. The low-affinity, IL-2R alpha chain cannot by itself transduce a mitogenic signal, whereas IL-2 stimulates resting lymphocytes through the intermediate-affinity, IL-2R beta receptor. We report here identification of the genomic locus for IL-2R beta. The exons are contained on four EcoRI fragments of 1.1, 9.2, 7.2, and 13.7 kilobases. The 1.1-kilobase EcoRI fragment lies at the 5'-most end of the genomic locus and contains promoter sequences. The promoter contains no TATA box-like elements but does contain the d(GT)n class of middle repetitive elements, which may play an interesting regulatory role. The IL-2R beta gene is localized to chromosome 22q11.2-q12, a region that is the locus for several lymphoid neoplasias.
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