Trial reportGastrointestinal endoscopy2013
Global quantitative assessment of the colorectal polyp burden in familial adenomatous polyposis by using a web-based tool.
Trial report in Gastrointestinal endoscopy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00503035 (Molecular Targeting of 15-LOX-1 for Apoptosis Induction in Human Colorectal Cancers), which is not on this map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Molecular Targeting of 15-LOX-1 for Apoptosis Induction in Human Colorectal Cancers
Who cites it
7 citing papers in PubMed.
- Endoscopic scoring indices for assessing disease severity in familial adenomatous polyposis: Systematic review.Endoscopy international open · 2024Review
- Celecoxib Colorectal Bioavailability and Chemopreventive Response in Patients with Familial Adenomatous Polyposis.Cancer prevention research (Philadelphia, Pa.) · 2022Article
- Assessing barriers to a rational chemoprevention trial design in young patients with familial adenomatous polyposis.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2017Article
- Chemoprevention of familial adenomatous polyposis.Familial cancer · 2016Review
- A proposed staging system and stage-specific interventions for familial adenomatous polyposis.Gastrointestinal endoscopy · 2016Article
- Chemoprevention of hereditary colon cancers: time for new strategies.Nature reviews. Gastroenterology & hepatology · 2016Review
- Cold snare polypectomy effectively reduces polyp burden in familial adenomatous polyposis.Endoscopy international open · 2016Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundAccurate measures of the total polyp burden in familial adenomatous polyposis (FAP) are lacking. Current assessment tools include polyp quantitation in limited-field photographs and qualitative total colorectal polyp burden by video.
objectiveTo develop global quantitative tools of the FAP colorectal adenoma burden.
designA single-arm, phase II trial. PATIENTS: Twenty-seven patients with FAP.
interventionTreatment with celecoxib for 6 months, with before-treatment and after-treatment videos posted to an intranet with an interactive site for scoring. MAIN OUTCOME MEASUREMENTS: Global adenoma counts and sizes (grouped into categories: <2 mm, 2-4 mm, and >4 mm) were scored from videos by using a novel Web-based tool. Baseline and end-of-study adenoma burden results were summarized by using 5 models. Correlations between pairs of reviewers were analyzed for each model.
resultsInterobserver agreement was high for all 5 measures of polyp burden. Measures that used both polyp count and polyp size had better interobserver agreement than measures based only on polyp count. The measure in which polyp counts were weighted according to diameter, calculated as (1) × (no. of polyps <2 mm) + (3) × (no. of polyps 2-4 mm) + (5) × (no. of polyps >4 mm) had the highest interobserver agreement (Pearson r = 0.978 for two gastroenterologists, 0.786 and 0.846 for the surgeon vs each gastroenterologist). Treatment reduced the polyp burden by these measurements in 70% to 89% of patients (P < .001). LIMITATIONS: Phase II study.
conclusionThis novel, Web-based polyp scoring method provides a convenient and reproducible way to quantify the global colorectal adenoma burden in FAP patients and a framework for developing a clinical staging system for FAP.
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