Trial reportAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2013
Urinary cystatin C and acute kidney injury after cardiac surgery.
Trial report in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Biomarkers of acute kidney injury after pediatric cardiac surgery: a meta-analysis of diagnostic test accuracy.European journal of pediatrics · 2022Pooled it
- Biomarkers of acute kidney injury in pediatric cardiac surgery.Pediatric nephrology (Berlin, Germany) · 2022Pooled it
- Accuracy of cystatin C in prediction of acute kidney injury in children; serum or urine levels: which one works better? A systematic review and meta-analysis.BMC nephrology · 2017Pooled it
- Urine Biomarkers and Perioperative Acute Kidney Injury: The Impact of Preoperative Estimated GFR.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2015Trial
- Adjudication of etiology of acute kidney injury: experience from the TRIBE-AKI multi-center study.BMC nephrology · 2014Trial
- Inflammatory Signatures and Biomarkers: The Renal-Vesical Axis in Alzheimer Progression.International neurourology journal · 2026Article
- Transparent AI-driven personalized risk prediction system for acute kidney injury after total hip arthroplasty.Scientific reports · 2025Article
- Advances in the diagnosis of early biomarkers for acute kidney injury: a literature review.BMC nephrology · 2025Review
- CysC as a predictor of left ventricular remodeling and major adverse cardiovascular events in patients with acute myocardial infarction.Frontiers in cardiovascular medicine · 2025Article
- Cystatin C and Kidney Function Recovery in Patients Requiring Continuous KRT for Acute Kidney Injury.Clinical journal of the American Society of Nephrology : CJASN · 2024Article
- Future embracing: exosomes driving a revolutionary approach to the diagnosis and treatment of idiopathic membranous nephropathy.Journal of nanobiotechnology · 2024Review
- Acute Kidney Injury Requiring Dialysis After Pediatric Heart Transplant.Pediatric transplantation · 2024Article
- Association of Urine Biomarkers With Acute Kidney Injury and Fluid Overload in Infants After Cardiac Surgery: A Single Center Ancillary Cohort of the Steroids to Reduce Systemic Inflammation After Infant Heart Surgery Trial.Critical care explorations · 2023Article
- Improving acute kidney injury diagnostic precision using biomarkers.Practical laboratory medicine · 2022Review
- The use of diagnostic tools for pediatric AKI: applying the current evidence to the bedside.Pediatric nephrology (Berlin, Germany) · 2021Review
- Acute kidney injury in the critically ill: an updated review on pathophysiology and management.Intensive care medicine · 2021Review
- Urinary EGF and MCP-1 and risk of CKD after cardiac surgery.JCI insight · 2021Article
- Results from the TRIBE-AKI Study found associations between post-operative blood biomarkers and risk of chronic kidney disease after cardiac surgery.Kidney international · 2021Article
- Development of acute kidney injury following pediatric cardiac surgery.Kidney research and clinical practice · 2020Review
- Developing Biomarker Panels to Predict Progression of Acute Kidney Injury After Cardiac Surgery.Kidney international reports · 2019Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundAcute kidney injury (AKI) is common after cardiac surgery and is associated with adverse patient outcomes. Urinary cystatin C (CysC) level is a biomarker of proximal tubule function and may increase earlier in AKI than serum creatinine level. STUDY
designProspective cohort study. SETTINGS &
participantsThe TRIBE AKI (Translational Research Investigating Biomarker Endpoints in AKI) Consortium prospectively enrolled 1,203 adults and 299 children and adolescents at 8 institutions in 2007-2009. INDEX TEST: Urinary CysC (in milligrams per liter) within the first 12 hours after surgery. OUTCOME: Serum creatinine-based AKI was defined as AKI Network stage 1 (mild AKI) and doubling of serum creatinine from the preoperative value or need for dialysis during hospitalization (severe AKI). OTHER MEASUREMENTS: Analyses were adjusted for characteristics used clinically for AKI risk stratification, including age, sex, race, estimated glomerular filtration rate, diabetes, hypertension, heart failure, nonelective surgery, cardiac catheterization within 72 hours, type of surgery, myocardial infarction, and cardiopulmonary bypass time longer than 120 minutes.
resultsUrinary CysC level measured in the early postoperative period (0-6 and 6-12 hours postoperatively) correlated with both mild and severe AKI in adults and children. However, after analyses were adjusted for other factors, the effect was attenuated for both forms of AKI in both cohorts. LIMITATIONS: Limited numbers of patients with severe AKI and in-hospital dialysis treatment.
conclusionsUrinary CysC values are not associated significantly with the development of AKI after cardiac surgery in adults and children.
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Registered trials
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