Evidence map›Paper›PMID 23332315›Full record

ReviewCurrent opinion in chemical biology2013

Emerging roles for protein S-palmitoylation in immunity from chemical proteomics.

Jacob S Yount, Mingzi M Zhang, Howard C Hang

Abstract readReview
In one paragraph

Review in Current opinion in chemical biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. ProteinOpen biology · 2021
    Review
  4. Article
  5. Protein Palmitoylation in Leukocyte Signaling and Function.Frontiers in cell and developmental biology · 2020
    Review
  6. Antiviral Protection by IFITM3 In Vivo.Current clinical microbiology reports · 2018
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Global Analysis of O-GlcNAc Glycoproteins in Activated Human T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2016
    Article
  13. Review
  14. Proteomic analysis of fatty-acylated proteins.Current opinion in chemical biology · 2016
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jacob S YountLaboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, New York, NY 10065, United States.
Mingzi M Zhang
Howard C Hang
Rockefeller University · US

Funding

Studies on Protein LipidationR01GM087544 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI HANG, HOWARD C · 2010 to 2023
$4.4M
Mechanistic analysis of a posttranslationally modified innate antiviral effectorR00AI095348 · NIAID · OHIO STATE UNIVERSITY · PI YOUNT, JACOB · 2013 to 2014
$494k
Mechanistic analysis of a posttranslationally modified innate antiviral effectorK99AI095348 · NIAID · ROCKEFELLER UNIVERSITY · PI YOUNT, JACOB · 2011 to 2011
$140k
NIAID NIH HHS 1K99AI095348NIAID NIH HHS K99 AI095348NIAID NIH HHS R00 AI095348NIGMS NIH HHS 1R01GM087544NIGMS NIH HHS R01 GM087544
6 · The paper itself

Abstract

The activation of innate and adaptive immune signaling pathways and effector functions often occur at cellular membranes and are regulated by complex mechanisms. Here we review the growing number of proteins which are known to be regulated by S-palmitoylation in immune cells emerging from recent advances in chemical proteomics. These chemical proteomic studies have highlighted the roles of this dynamic lipid modification in regulating the specificity and strength of immune responses in different lymphocyte populations.

Indexed as

ImmunityLipoylationAnimalsHumansLeukocytesLymphocytesMononuclear Phagocyte SystemProteomeProteomicsProteome

Identifiers

PMID23332315
PMCPMC4000526
OpenAlexW2072440144

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.