ArticleBiophysical journal2013
Quantitative LSPR imaging for biosensing with single nanostructure resolution.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Optical Analysis of Cyclic Voltammetry of Ferrocenemethanol: A Comparative Study of SPR and LSPR.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- Large Scale Fabrication of Ordered Gold Nanoparticle-Epoxy Surface Nanocomposites and Their Application as Label-Free Plasmonic DNA Biosensors.ACS applied materials & interfaces · 2020Article
- Real-Time Monitoring and Detection of Single-Cell Level Cytokine Secretion Using LSPR Technology.Micromachines · 2020Article
- Metadevices with Potential Practical Applications.Molecules (Basel, Switzerland) · 2019Review
- Article
- Article
- A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions.Journal of visualized experiments : JoVE · 2015Article
- Quantitative imaging of protein secretions from single cells in real time.Biophysical journal · 2013Article
- Optimizing Nanoplasmonic Biosensor Sensitivity with Orientated Single Domain Antibodies.Plasmonics (Norwell, Mass.)Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Localized surface plasmon resonance (LSPR) imaging has the potential to map complex spatio-temporal variations in analyte concentration, such as those produced by protein secretions from live cells. A fundamental roadblock to the realization of such applications is the challenge of calibrating a nanoscale sensor for quantitative analysis. Here, we introduce a new, to our knowledge, LSPR imaging and analysis technique that enables the calibration of hundreds of individual gold nanostructures in parallel. The calibration allowed us to map the fractional occupancy of surface-bound receptors at individual nanostructures with nanomolar sensitivity and a temporal resolution of 225 ms. As a demonstration of the technique's applicability to molecular and cell biology, the calibrated array was used for the quantitative LSPR imaging of anti-c-myc antibodies harvested from a cultured 9E10 hybridoma cell line without the need for further purification or processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.