ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2013
Early plasma soluble receptor for advanced glycation end-product levels are associated with bronchiolitis obliterans syndrome.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- The Use of Advanced Glycation End-Product Measurements to Predict Post-Operative Complications After Cardiac Surgery.Journal of clinical medicine · 2025Review
- The Remarkable Roles of the Receptor for Advanced Glycation End Products (RAGE) and Its Soluble Isoforms in COVID-19: The Importance of RAGE Pathway in the Lung Injuries.Indian journal of clinical biochemistry : IJCB · 2023Review
- The role of innate immunity in the long-term outcome of lung transplantation.Annals of translational medicine · 2020Review
- An obligatory role for club cells in preventing obliterative bronchiolitis in lung transplants.JCI insight · 2019Article
- Protein biomarkers associated with primary graft dysfunction following lung transplantation.American journal of physiology. Lung cellular and molecular physiology · 2017Review
- Mechanisms of graft rejection after lung transplantation.Current opinion in organ transplantation · 2017Review
- Blood Gene Expression Predicts Bronchiolitis Obliterans Syndrome.Frontiers in immunology · 2017Article
- Biomarkers of lung injury in cardiothoracic surgery.Disease markers · 2015Review
- Update in lung transplantation 2013.American journal of respiratory and critical care medicine · 2014Article
- Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Early epithelial injury after lung transplantation may contribute to development of bronchiolitis obliterans syndrome (BOS). We evaluated the relationship between early postoperative soluble receptor for advanced glycation end-product (sRAGE) levels, a marker of type I alveolar cell injury and BOS. We performed a cohort study of 106 lung transplant recipients between 2002 and 2006 at the University of Pennsylvania with follow-up through 2010. Plasma sRAGE was measured 6 and 24 h after transplantation. Cox proportional hazards models were used to evaluate the association between sRAGE and time to BOS, defined according to ISHLT guidelines. Sixty (57%) subjects developed BOS. The average time to BOS was 3.4 years. sRAGE levels measured at 6 h (HR per SD of sRAGE: 1.69, 95% CI: 1.11, 2.57, p = 0.02) and 24 h (HR per SD of sRAGE: 1.74, 95% CI: 1.14, 2.65, p = 0.01) were associated with an increased hazard of BOS. Multivariable Cox regression indicated this relationship was independent of potential confounders. Elevated plasma sRAGE levels measured in the immediate postoperative period are associated with the development of BOS. Early epithelial injury after transplantation may contribute to the development of fibrosis in BOS.
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Registered trials
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