ArticleAddiction biology2014
Relation between corticosterone and fear-related behavior in mice selectively bred for high or low alcohol preference.
Article in Addiction biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Line- and sex-dependent effects of juvenile stress on contextual fear- and anxiety-related behavior in high- and low-alcohol-preferring mouse lines.Behavioural brain research · 2024Article
- Adolescent social isolation increases binge-like alcohol drinking in male but not female high-alcohol-preferring mice.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Article
- The Effect of 2.45 GHz Electromagnetic Fields on Fear Memory Extinction in Male Rats.Journal of lasers in medical sciences · 2022Article
- A narrative review of the epigenetics of post-traumatic stress disorder and post-traumatic stress disorder treatment.Frontiers in psychiatry · 2022Review
- Effects of treadmill exercise on anxiety-like behavior in association with changes in estrogen receptors ERα, ERβ and oxytocin of C57BL/6J female mice.IBRO neuroscience reports · 2021Article
- Anxiety disturbs the blood plasma metabolome in acute coronary syndrome patients.Scientific reports · 2021Article
- Juvenile stress facilitates safety learning in male and female high alcohol preferring mice.Behavioural brain research · 2021Article
- Endocannabinoids and Fear-Related Behavior in Mice Selectively Bred for High or Low Alcohol Preference.Brain sciences · 2019Article
- Novel behavioral assays of spontaneous and precipitated THC withdrawal in mice.Drug and alcohol dependence · 2018Article
- Exposure to an obesogenic diet during adolescence leads to abnormal maturation of neural and behavioral substrates underpinning fear and anxiety.Brain, behavior, and immunity · 2018Article
- Effects of Nicotine on Alcohol Drinking in Female Mice Selectively Bred for High or Low Alcohol Preference.Alcoholism, clinical and experimental research · 2018Article
- Analyses of differentially expressed genes after exposure to acute stress, acute ethanol, or a combination of both in mice.Alcohol (Fayetteville, N.Y.) · 2017Article
- Genetic correlation between alcohol preference and conditioned fear: Exploring a functional relationship.Alcohol (Fayetteville, N.Y.) · 2017Article
- The FKBP5 Gene Affects Alcohol Drinking in Knockout Mice and Is Implicated in Alcohol Drinking in Humans.International journal of molecular sciences · 2016Article
- Effects of Chronic Stress on Alcohol Reward- and Anxiety-Related Behavior in High- and Low-Alcohol Preferring Mice.Alcoholism, clinical and experimental research · 2016Article
- Effect of acute swim stress on plasma corticosterone and brain monoamine levels in bidirectionally selected DxH recombinant inbred mouse strains differing in fear recall and extinction.Stress (Amsterdam, Netherlands) · 2014Article
- Substance abuse, memory, and post-traumatic stress disorder.Neurobiology of learning and memory · 2014Review
- Effects of stress, acute alcohol treatment, or both on pre-pulse inhibition in high- and low-alcohol preferring mice.Alcohol (Fayetteville, N.Y.) · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Blunted cortisol responses to stress or trauma have been linked with genetic (familial) risk for both alcoholism and post-traumatic stress disorder (PTSD). Mouse lines selectively bred for high (HAP) or low (LAP) alcohol preference may be a relevant model of genetic risk for co-morbid alcoholism and PTSD in humans. HAP mice show greater fear-potentiated startle (FPS), a model used to study PTSD, than LAP mice. The relation between corticosterone (CORT) and FPS behavior was explored in four experiments. Naïve male and female HAP2 and LAP2 mice received fear-conditioning or control treatments, and CORT levels were measured before and immediately after fear-conditioning or FPS testing. In two other experiments, HAP2 mice received CORT (1.0, 5.0 or 10.0 mg/kg) or a glucocorticoid receptor antagonist (mifepristone; 25.0 and 50.0 mg/kg) 30 minutes before fear conditioning. HAP2 mice exposed to fear conditioning and to control foot shock exposures showed lower CORT after the fear-conditioning and FPS testing sessions than LAP2 mice. A trend toward higher FPS was seen in HAP2 mice pretreated with 10.0 mg/kg CORT, and CORT levels were the lowest in this group, suggesting negative feedback inhibition of CORT release. Mifepristone did not alter FPS. Overall, these results are consistent with data in humans and rodents indicating that lower cortisol/CORT levels after stress are associated with PTSD/PTSD-like behavior. These findings in HAP2 and LAP2 mice suggest that a blunted CORT response to stress may be a biological marker for greater susceptibility to develop PTSD in individuals with increased genetic risk for alcoholism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.