Trial reportEuropean journal of oral sciences2013
Somatosensory profiling of intra-oral capsaicin and menthol in healthy subjects.
Trial report in European journal of oral sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 34 citations in OpenAlex.
- A new protocol to evaluate the effect of topical anesthesia.Anesthesia progress · 2014Trial
- Quantitative sensory testing in oral disorders: an update on methods and clinical implications.Journal of dental anesthesia and pain medicine · 2026Review
- Article
- Investigation of Sensory and Neuropsychological Parameters in Migraine Sufferers: A Cross-Sectional Study with Negative Findings.Neurology and therapy · 2025Article
- Effects of pain associated with orthodontic tooth movement on tactile sensation of periodontal ligaments.Clinical oral investigations · 2023Article
- Article
- Drop homotopic effects of masseter-muscle pain on somatosensory sensitivity in healthy participants.Scientific reports · 2021Article
- Mechanical sensitivity and psychological factors in patients with burning mouth syndrome.Clinical oral investigations · 2019Article
- Perceptual distortion of the tongue by lingual nerve block and topical application of capsaicin in healthy women.Clinical oral investigations · 2017Article
- Fine motor control of the jaw following alteration of orofacial afferent inputs.Clinical oral investigations · 2017Article
- Influence of topical application of capsaicin, menthol and local anesthetics on intraoral somatosensory sensitivity in healthy subjects: temporal and spatial aspects.Experimental brain research · 2015Article
- Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
This study was designed to investigate the effect of surrogate orofacial pain models on the quantitative sensory testing (QST) profile in healthy participants. Capsaicin, menthol, or saline (control) were applied topically onto the gingiva of 15 healthy subjects for 15 min. During application, the subjects rated pain intensity on a score of 0-10, on an electronic visual analog scale (VAS). A standardized intra-oral QST protocol was performed before and immediately after application. Data obtained before and after application were compared using rank-sum tests, and QST profiles were made after Z-transformation. Application of capsaicin caused moderate levels of pain (VAS(peak) = 6.0 ± 0.7), and application of menthol produced mild levels of pain (VAS(peak) = 1.8 ± 0.6). Capsaicin induced hypersensitivity to warmth, heat pain and cold pain and hyposensitivity to mechanical stimuli. Menthol induced hypersensitivity to cold and warmth. Saline caused hypersensitivity to heat pain and hyposensitivity to mechanical stimuli. However, somatosensory profiles from Z-scores demonstrated sensory gains regarding warmth detection and heat pain only after application of capsaicin. In conclusion, a standardized battery of QST showed somatosensory changes after application of capsaicin, menthol and saline to the gingiva. However, the Z-score-based profiles may only reflect the most prominent somatosensory changes and thus represent a conservative approach for evaluation of data.
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Registered trials
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