Trial reportClinical endocrinology2013
Inhibition of Pref-1 (preadipocyte factor 1) by oestradiol in adolescent girls with anorexia nervosa is associated with improvement in lumbar bone mineral density.
Trial report in Clinical endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- State of the art systematic review of bone disease in anorexia nervosa.The International journal of eating disorders · 2016Pooled it
- Identification and validation of core genes for type 2 diabetes mellitus by integrated analysis of single-cell and bulk RNA-sequencing.European journal of medical research · 2023Article
- Bone changes post-sleeve gastrectomy in relation to body mass and hormonal changes.European journal of endocrinology · 2023Observational
- Changes in Sex Steroids and Enteric Peptides After Sleeve Gastrectomy in Youth in Relation to Changes in Bone Parameters.The Journal of clinical endocrinology and metabolism · 2022Observational
- Circulating levels of DLK1 and glucose homeostasis in girls with obesity: A pilot study.Frontiers in endocrinology · 2022Article
- Bone Metabolism in Adolescents Undergoing Bariatric Surgery.The Journal of clinical endocrinology and metabolism · 2021Review
- Bone Marrow Adiposity: Basic and Clinical Implications.Endocrine reviews · 2019Review
- Impact of Route of Estrogen Administration on Bone Turnover Markers in Oligoamenorrheic Athletes and Its Mediators.The Journal of clinical endocrinology and metabolism · 2019Article
- Anorexia Nervosa and Bone.Current opinion in endocrine and metabolic research · 2018Article
- Marrow Adipose Tissue: Its Origin, Function, and Regulation in Bone Remodeling and Regeneration.Stem cells international · 2018Review
- Eating disorders and bone metabolism in women.Current opinion in pediatrics · 2017Review
- Serum Preadipocyte Factor 1 Levels Are Not Associated with Bone Mineral Density among Healthy Postmenopausal Korean Women.Endocrinology and metabolism (Seoul, Korea) · 2017Article
- Increased sclerostin and preadipocyte factor-1 levels in prepubertal rhythmic gymnasts: associations with bone mineral density, body composition, and adipocytokine values.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Observational
- Anorexia nervosa and bone.The Journal of endocrinology · 2014Review
- Endocrinology of anorexia nervosa in young people: recent insights.Current opinion in endocrinology, diabetes, and obesity · 2014Review
- Anorexia nervosa, obesity and bone metabolism.Pediatric endocrinology reviews : PER · 2013Review
- Pref-1, a gatekeeper of adipogenesis.Frontiers in endocrinology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
objectiveAdolescents with anorexia nervosa (AN) are amenorrheic and have decreased bone mass accrual and low bone mineral density (BMD). The regulation of mesenchymal stem cell differentiation is an important factor governing bone formation. Preadipocyte factor 1 (Pref-1), an inhibitor of adipocyte and osteoblast differentiation, is elevated in states of oestrogen deficiency. In this study, we aim to (i) investigate effects of transdermal oestradiol on Pref-1 in adolescent girls with AN, and (ii) examine associations of changes in Pref-1 with changes in lumbar BMD and bone turnover markers.
designAdolescent girls with AN and normal-weight controls were studied cross-sectionally. Girls with AN were examined longitudinally in a double-blind study and received transdermal oestradiol (plus cyclic medroxyprogesterone) or placebo for 12 months. PATIENTS: Sixty-nine girls (44 with AN, 25 normal-weight controls) 13-18 years were studied at baseline; 22 AN girls were followed prospectively. MEASUREMENTS: Pref-1 levels, bone formation and resorption markers, and BMD.
resultsPref-1 levels decreased in girls with AN after treatment with transdermal oestradiol compared with placebo (-0·015 ± 0·016 vs 0·060±0·026 ng/ml, P = 0·01), although at baseline, levels did not differ in AN vs controls (0·246 ± 0·015 vs 0·267 ± 0·022 ng/ml). Changes in Pref-1 over 12 months correlated inversely with changes in lumbar BMD (r = -0·48, P = 0·02) and positively with changes in CTX (r = 0·73, P = 0·006).
conclusionsFor the first time, we show that Pref-1 is negatively regulated by oestradiol in adolescent girls with AN. Inhibition of Pref-1 may mediate the beneficial effects of transdermal oestradiol replacement on BMD in girls with AN.
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