Evidence map›Paper›PMID 23330624›Full record

ArticleThe American journal of orthopsychiatry2013

Prenatal methamphetamine exposure, home environment, and primary caregiver risk factors predict child behavioral problems at 5 years.

Jean Twomey, Linda LaGasse, Chris Derauf, Elana Newman, Rizwan Shah, Lynne Smith, Amelia Arria, Marilyn Huestis, Sheri DellaGrotta, Mary Roberts and 3 more

Abstract read
In one paragraph

Article in The American journal of orthopsychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Methamphetamine: burden, mechanism and impact on pregnancy, the fetus, and newborn.Journal of perinatology : official journal of the California Perinatal Association · 2022
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Developmental consequences of fetal exposure to drugs: what we know and what we still must learn.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015
    Review
  12. Review
  13. Pregnancy and fetal loss reported by methamphetamine-using women.Substance abuse : research and treatment · 2014
    Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jean TwomeyWarren Alpert Medical School at Brown University, USA. jtwomey@wihri.org
Linda LaGasse
Chris Derauf
Elana Newman
Rizwan Shah
Lynne Smith
Amelia Arria
Marilyn Huestis
Sheri DellaGrotta
Mary Roberts
Lynne Dansereau
Charles Neal
Barry Lester

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Prental Methamphetamine Exposure and Child DevelopmentR01DA014948 · NIDA · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI LESTER, BARRY M. · 2001 to 2013
$14.5M
Monitoring In Utero Drug ExposureZIADA000433 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI SCHEIDWEILER, KARL · 2009 to 2016
$2.9M
Monitoring In Utero Drug ExposureZ01DA000433 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI HUESTIS, MARILYN · 2000 to 2008
$1.3M
Intramural NIH HHS Z01 DA000433Intramural NIH HHS ZIA DA000433NCATS NIH HHS UL1 TR000124NIDA NIH HHS R01 DA014948
6 · The paper itself

Abstract

This study investigated the prospective association between prenatal methamphetamine (MA) exposure and child behavioral problems at 5 years while also examining the home environment at 30 months and several primary caregiver (PC) risk factors. Participants were 97 MA-exposed and 117 comparison children and their PCs enrolled in the Infant Development, Environment and Lifestyle Study. Hypotheses were that child behaviors would be adversely impacted by (a) prenatal MA exposure, (b) home environments that provided less developmental stimulation and emotional responsiveness to the child, and (c) the presence of PC psychological symptoms and other risk factors. Prenatal MA exposure was associated with child externalizing behavioral problems at 5 years. Home environments that were more conducive to meeting children's developmental and emotional needs were associated with fewer internalizing and externalizing behavioral problems. Independent of prenatal MA exposure, PC parenting stress and psychological symptoms were associated with increased child behavioral problems. Findings suggest prenatal MA exposure may contribute to externalizing behavioral problems in early childhood and the importance of considering possible vulnerabilities related to prenatal MA exposure in the context of the child's caregiving environment.

Indexed as

Social EnvironmentCaregiversCentral Nervous System StimulantsChild BehaviorChild Behavior DisordersChild, PreschoolFemaleHumansMaleMethamphetamineMothersPregnancyPrenatal Exposure Delayed EffectsRisk FactorsCentral Nervous System StimulantsMethamphetamine

Identifiers

PMID23330624
PMCPMC3721329

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.