Trial reportInternational journal of medical sciences2013
Creatine metabolism and safety profiles after six-week oral guanidinoacetic acid administration in healthy humans.
Trial report in International journal of medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Medium-term Oral Guanidinoacetic Acid (GAA) Administration on Human Performance, Body Composition, and Metabolic Outcomes in Physically Active Men and Women
Guanidinoacetic Acid Loading for Chronic Fatigue Syndrome
Who cites it
19 citing papers in PubMed, 56 citations in OpenAlex.
- Trial
- Guanidinoacetic acid loading affects plasma γ-aminobutyric acid in healthy men.European journal of nutrition · 2015Trial
- Dose-response effects of oral guanidinoacetic acid on serum creatine, homocysteine and B vitamins levels.European journal of nutrition · 2014Trial
- An indirect competitive ELISA for determination of guanidine acetic acid in animal feed.Scientific reports · 2025Article
- [Analysis of ischemic stroke biomarkers based on non-targeted metabolomics].Se pu = Chinese journal of chromatography · 2025Article
- Food-sourced guanidinoacetic acid and methylation cycle biomarkers in individuals aged one year and older: a population-based cross-sectional study.European journal of nutrition · 2024Article
- Guanidinoacetic acid in human nutrition: Beyond creatine synthesis.Food science & nutrition · 2023Review
- Guanidine acetic acid supplementation altered plasma and tissue free amino acid profiles in finishing pigs.Porcine health management · 2022Article
- Safety of Dietary Guanidinoacetic Acid: A Villain of a Good Guy?Nutrients · 2021Review
- Effects of guanidinoacetic acid supplementation on nitrogen retention and methionine flux in cattle.Journal of animal science · 2021Article
- Response of laying hens to l-arginine, l-citrulline and guanidinoacetic acid supplementation in reduced protein diet.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2021Article
- Short-term GAA loading: Responders versus nonresponders analysis.Food science & nutrition · 2020Article
- Effect of post-ruminal guanidinoacetic acid supplementation on creatine synthesis and plasma homocysteine concentrations in cattle.Journal of animal science · 2020Article
- Guanidino-Acetic Acid: A Scarce Substance in Biomass That Can Regulate Postmortem Meat Glycolysis of Broilers Subjected to Pre-slaughter Transportation.Frontiers in bioengineering and biotechnology · 2020Article
- Dietary guanidinoacetic acid does not accumulate in the brain of healthy men.European journal of nutrition · 2018Article
- Guanidinoacetic Acid Regulates Myogenic Differentiation and Muscle Growth Through miR-133a-3p and miR-1a-3p Co-mediated Akt/mTOR/S6K Signaling Pathway.International journal of molecular sciences · 2018Article
- Safety and efficacy of guanidinoacetic acid for chickens for fattening, breeder hens and roosters, and pigs.EFSA journal. European Food Safety Authority · 2016Article
- Cellular bioenergetics of guanidinoacetic acid: the role of mitochondria.Journal of bioenergetics and biomembranes · 2015Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesGuanidinoacetic acid (GAA) is a natural precursor of creatine, yet the potential use of GAA as a nutritional additive for restoring creatine availability in humans has been limited by unclear efficacy and safety after exogenous GAA administration. The present study evaluated the effects of orally administered GAA on serum and urinary GAA, creatine and creatinine concentration, and on the occurrence of adverse events in healthy humans. METHODS AND
resultsTwenty-four healthy volunteers were randomized in a double-blind design to receive either GAA (2.4 grams daily) or placebo (PLA) by oral administration for 6 weeks. CLINICAL
trial registrationwww.clinicaltrials.gov, identification number NCT01133899. Serum creatine and creatinine increased significantly from before to after administration in GAA-supplemented participants (P < 0.05). The proportion of participants who reported minor side effects was 58.3% in the GAA group and 45.5% in the placebo group (P = 0.68). A few participants experienced serum creatine levels above 70 µmol/L.
conclusionExogenous GAA is metabolized to creatine, resulting in a significant increase of fasting serum creatine after intervention. GAA had an acceptable side-effects profile with a low incidence of biochemical abnormalities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.