ArticleJournal of applied physiology (Bethesda, Md. : 1985)2013
Astrocytic leptin-receptor knockout mice show partial rescue of leptin resistance in diet-induced obesity.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Secretion Patterns of Leptin: A Key Component in the Regulation of Energy Homeostasis and Its Therapeutic Applications.Biomolecules · 2026Review
- Hypothalamic Astrocytes as a Specialized and Responsive Cell Population in Obesity.International journal of molecular sciences · 2021Review
- Oxidative stress and neuroinflammation in a rat model of co-morbid obesity and psychogenic stress.Behavioural brain research · 2021Article
- Tissue-Specific Effects of Leptin on Glucose and Lipid Metabolism.Endocrine reviews · 2021Review
- Immunometabolic Changes in Glia - A Potential Role in the Pathophysiology of Obesity and Diabetes.Neuroscience · 2020Review
- Deletion of astrocytic BMAL1 results in metabolic imbalance and shorter lifespan in mice.Glia · 2020Article
- Dorsal vagal complex and hypothalamic glia differentially respond to leptin and energy balance dysregulation.Translational psychiatry · 2020Article
- Role of astroglia in diet-induced central neuroplasticity.Journal of neurophysiology · 2019Review
- Astrocytes, emerging stars of energy homeostasis.Cell stress · 2018Article
- Leptin Receptor Expression in Mouse Intracranial Perivascular Cells.Frontiers in neuroanatomy · 2018Article
- Physiology of Astroglia.Physiological reviews · 2018Review
- The cellular and molecular bases of leptin and ghrelin resistance in obesity.Nature reviews. Endocrinology · 2017Review
- Glia: silent partners in energy homeostasis and obesity pathogenesis.Diabetologia · 2017Review
- Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding.eLife · 2016Article
- Genetic variability to diet-induced hippocampal dysfunction in BXD recombinant inbred (RI) mouse strains.Behavioural brain research · 2015Article
- Role of Astrocytes in Leptin Signaling.Journal of molecular neuroscience : MN · 2015Article
- Leptin: a biomarker for sleep disorders?Sleep medicine reviews · 2014Article
- Article
- The contribution of hypothalamic macroglia to the regulation of energy homeostasis.Frontiers in systems neuroscience · 2014Review
- Hypersomnolence and reduced activity in pan-leptin receptor knockout mice.Journal of molecular neuroscience : MN · 2013Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
To determine how astrocytic leptin signaling regulates the physiological response of mice to diet-induced obesity (DIO), we performed metabolic analyses and hypothalamic leptin signaling assays on astrocytic leptin-receptor knockout (ALKO) mice in which astrocytes lack functional leptin receptor (ObR) signaling. ALKO mice and wild-type (WT) littermate controls were studied at different stages of DIO with measurement of body wt, percent fat, metabolic activity, and biochemical parameters. When fed regular chow, the ALKO mice had similar body wt, percent fat, food intake, heat dissipation, respiratory exchange ratio, and activity as their WT littermates. There was no change in blood concentrations of triglyceride, soluble leptin receptor (sObR), mRNA for leptin and uncoupling protein 1 (UCP1) in adipose tissue, and insulin sensitivity. Unexpectedly, in response to a high-fat diet the ALKO mice had attenuated hyperleptinemia and sObR, a lower level of leptin mRNA in subcutaneous fat, and a paradoxical increase in UCP1 mRNA. Thus, ALKO mice did not show the worsening of obesity that occurs with normal WT mice and the neuronal ObR mutation that results in morbid obesity. The findings are consistent with a competing, counterregulatory model between neuronal and astrocytic leptin signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.