Evidence map›Paper›PMID 23329606›Full record

SynthesisSports medicine (Auckland, N.Z.)2013

The effect of exercise on the cardiovascular risk factors constituting the metabolic syndrome: a meta-analysis of controlled trials.

Nele Pattyn, Véronique A Cornelissen, Saeed R Toghi Eshghi, Luc Vanhees

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Sports medicine (Auckland, N.Z.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed, 10 pooled it
40.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

113 citing papers in PubMed, 10 syntheses or guidelines pooled it, 260 citations in OpenAlex.

  1. Efficacy of Exercise-Based Interventions for Metabolic Syndrome: An Umbrella Review With Meta-Analyses.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
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  4. Exercise interventions for adults after liver transplantation.The Cochrane database of systematic reviews · 2023
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53 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nele PattynDepartment of Rehabilitation Sciences, KU Leuven, Louvain, Belgium. neleke_pattyn@hotmail.com
Véronique A Cornelissen
Saeed R Toghi Eshghi
Luc Vanhees
KU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNumerous meta-analyses have investigated the effect of exercise in different populations and for single cardiovascular risk factors, but none have specifically focused on the metabolic syndrome (MetS) patients and the concomitant effect of exercise on all associated cardiovascular risk factors.

objectiveThe aim of this article was to perform a systematic review with a meta-analysis of randomized and clinical controlled trials (RCTs, CTs) investigating the effect of exercise on cardiovascular risk factors in patients with the MetS.

methodsRCTs and CTs ≥4 weeks investigating the effect of exercise in healthy adults with the MetS and published in a peer-reviewed journal up to November 2011 were included. Primary outcome measures were changes in waist circumference (WC), systolic and diastolic blood pressure, high-density lipoprotein cholesterol (HDL-C), triglycerides and fasting plasma glucose. Peak oxygen uptake ([Formula: see text]) was a secondary outcome. Random and fixed-effect models were used for analyses and data are reported as means and 95% confidence intervals (CIs).

resultsSeven trials were included, involving nine study groups and 206 participants (128 in exercise group and 78 in control group). Significant mean reductions in WC -3.4 (95% CI -4.9, -1.8) cm, blood pressure -7.1 (95% CI -9.03, -5.2)/-5.2 (95% CI -6.2, -4.1) mmHg and a significant mean increase in HDL-C +0.06 (95% CI +0.03, +0.09) mmol/L were observed after dynamic endurance training. Mean plasma glucose levels -0.31 (95% CI -0.64, 0.01; p = 0.06) mmol/L and triglycerides -0.05 (95% CI -0.20, 0.09; p = 0.47) mmol/L remained statistically unaltered. In addition, a significant mean improvement in [Formula: see text] of +5.9 (95% CI +3.03, +8.7) mL/kg/min or 19.3% was found.

conclusionsOur results suggest that dynamic endurance training has a favourable effect on most of the cardiovascular risk factors associated with the MetS. However, in the search for training programmes that optimally improve total cardiovascular risk, further research is warranted, including studies on the effects of resistance training and combined resistance and endurance training.

Indexed as

Exercise TherapyBlood GlucoseBlood PressureCholesterol, HDLConfidence IntervalsHumansMetabolic SyndromeOxygen ConsumptionPhysical EnduranceRandomized Controlled Trials as TopicTriglyceridesWaist CircumferenceBlood GlucoseCholesterol, HDLTriglycerides

Identifiers

PMID23329606
PMCPMC3693431
OpenAlexW2012658870

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.