ReviewPediatric research2013
Genome-wide expression profiling in pediatric septic shock.
Review in Pediatric research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Precision medicine in pediatric sepsis-associated acute kidney injury: when systemic heterogeneity meets organ-level heterogeneity.World journal of pediatrics : WJP · 2026Article
- Genome-wide association study of paediatric bacteraemia and sepsis.EBioMedicine · 2026Article
- Proteomic profiling and pathway analyses reveal molecular signatures and immune networks in pediatric sepsis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Precision Microbial Therapeutics for Infertility: Next-Generation Probiotics, Engineered Biologics and Translational Pathways.Microbial biotechnology · 2026Review
- Multi-omic and computational approaches for biomarker discovery and clinical translation in pediatric sepsis.Frontiers in pharmacology · 2026Review
- Fever in Children with Cancer: Pathophysiological Insights Using Blood Transcriptomics.International journal of molecular sciences · 2025Article
- Pediatric Sepsis - Sailing the Unchartered Waters with Omics.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Whole blood transcriptomics identifies subclasses of pediatric septic shock.Critical care (London, England) · 2023Article
- Identification of key biomarkers in neonatal sepsis by integrated bioinformatics analysis and clinical validation.Heliyon · 2022Article
- Ecthyma gangrenosum and severe neutropenic sepsis caused byThe Journal of international medical research · 2022Article
- Challenging molecular dogmas in human sepsis using mathematical reasoning.EBioMedicine · 2022Review
- [Effect of protein C activator fromNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021Article
- Transcriptomic Profiles in Children With Septic Shock With or Without Immunoparalysis.Frontiers in immunology · 2021Article
- SARS-CoV-2/COVID-19: Evolving Reality, Global Response, Knowledge Gaps, and Opportunities.Shock (Augusta, Ga.) · 2020Review
- Effect of zinc supplementation on relative expression of immune response genes in neonates with sepsis: A preliminary study.The Indian journal of medical research · 2020Article
- The soluble tumor necrosis factor receptor 1 as a potential early diagnostic and prognostic markers in intensive care unit patients with severe infections.Central-European journal of immunology · 2020Article
- Large-scale reduction of tyrosine kinase activities in human monocytes stimulated in vitro with N. meningitidis.PloS one · 2018Article
- Article
- Neutrophil dysregulation during sepsis: an overview and update.Journal of cellular and molecular medicine · 2017Review
- LPS Stimulation of Cord Blood Reveals a Newborn-Specific Neutrophil Transcriptomic Response and Cytokine Production.Shock (Augusta, Ga.) · 2017Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
For nearly a decade, our research group has had the privilege of developing and mining a multicenter, microarray-based, genome-wide expression database of critically ill children (≤10 y of age) with septic shock. Using bioinformatic and systems biology approaches, the expression data generated through this discovery-oriented, exploratory approach have been leveraged for a variety of objectives, which are reviewed here. Fundamental observations include widespread repression of gene programs corresponding to the adaptive immune system and biologically significant differential patterns of gene expression across developmental age groups. The data have also identified gene expression-based subclasses of pediatric septic shock having clinically relevant phenotypic differences. The data have also been leveraged for the discovery of novel therapeutic targets, as well as for the discovery and development of novel stratification and diagnostic biomarkers. Almost a decade of genome-wide expression profiling in pediatric septic shock is now demonstrating tangible results. The studies have progressed from an initial discovery-oriented and exploratory phase to a new phase in which the data are being translated and applied to address several areas of clinical need.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.