Evidence map›Paper›PMID 23328974›Full record

ArticleChemical communications (Cambridge, England)2013

Immunomodulation and the quorum sensing molecule 3-oxo-C12-homoserine lactone: the importance of chemical scaffolding for probe development.

Amanda L Garner, Jing Yu, Anjali K Struss, Gunnar F Kaufmann, Vladimir V Kravchenko, Kim D Janda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical communications (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. β-Lactams from the Ocean.Marine drugs · 2023
    Review
  2. Immunoediting role for major vault protein in apoptotic signaling induced by bacterialProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Amanda L GarnerDepartment of Chemistry, The Skaggs Institute for Chemical Biology and The Worm Institute for Research and Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Jing Yu
Anjali K Struss
Gunnar F Kaufmann
Vladimir V Kravchenko
Kim D Janda

Funding

Chemical Strategies to Manipulate A1-2 Signaling in Bacterial PathogensR01AI077644 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI JANDA, KIM · 2010 to 2014
$2.3M
Biological Implications of Tetramic AcidR21AI079503 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI JANDA, KIM · 2009 to 2010
$522k
Oral Biofilms and the Immune SystemR21DE018452 · NIDCR · SCRIPPS RESEARCH INSTITUTE, THE · PI JANDA, KIM · 2008 to 2009
$521k
Bacterial acyl homoserine lactones as immune modulators and drug targetsR21AI085324 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI KAUFMANN, GUNNAR JOERG FLORIS · 2010 to 2011
$519k
Studies of bacterial autoinducers:recognition and modulation of host processesR56AI094348 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI KRAVCHENKO, VLADIMIR V · 2012 to 2012
$379k
NIAID NIH HHS AI077644NIAID NIH HHS AI079503NIAID NIH HHS AI085324NIAID NIH HHS AI094348NIAID NIH HHS R01 AI077644NIAID NIH HHS R21 AI079503NIAID NIH HHS R21 AI085324NIAID NIH HHS R56 AI094348NIDCR NIH HHS DE018452NIDCR NIH HHS R21 DE018452
6 · The paper itself

Abstract

As a guide for chemical probe design, focused analogue synthetic studies were undertaken upon the lactone ring of 3-oxo-C(12)-homoserine lactone. We have concluded that hydrolytic instability of the heterocyclic ring is pivotal for its ability to modulate immune signaling and probe preparation was aligned with these findings.

Indexed as

4-ButyrolactoneAnimalsBone Marrow CellsEndoplasmic Reticulum StressHomoserineImmunomodulationMacrophagesMiceNF-kappa BOxidation-ReductionPoly(ADP-ribose) PolymerasesPseudomonas aeruginosaQuorum Sensing4-ButyrolactoneHomoserinehomoserine lactoneN-(3-oxododecanoyl)homoserine lactoneNF-kappa BPoly(ADP-ribose) Polymerases

Identifiers

PMID23328974
PMCPMC3566768

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.