ArticleNeurobiology of disease2013
Deletion of Nrf2 impairs functional recovery, reduces clearance of myelin debris and decreases axonal remyelination after peripheral nerve injury.
Article in Neurobiology of disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 52 citations in OpenAlex.
- DA.Frontiers in cell and developmental biology · 2025Article
- Enhancement of Heme-Oxygenase 1 in the Injured Peripheral Nerve Following Sulforaphane Administration Fosters Regeneration via Proliferation and Maintenance of Repair Schwann Cells.Antioxidants (Basel, Switzerland) · 2024Article
- Roles of Macrophages and Their Interactions with Schwann Cells After Peripheral Nerve Injury.Cellular and molecular neurobiology · 2023Review
- Effects of Ischemic Stroke on Interstitial Fluid Clearance in Mouse Brain: a Bead Study.Cellular and molecular neurobiology · 2023Article
- Beneficial Effect of Bee Venom and Its Major Components on Facial Nerve Injury Induced in Mice.Biomolecules · 2023Article
- Exogenous Antioxidants in Remyelination and Skeletal Muscle Recovery.Biomedicines · 2022Review
- The Potential Benefits of Dietary Polyphenols for Peripheral Nerve Regeneration.International journal of molecular sciences · 2022Review
- Lotus essential oil improves neurite elongation and facilitates functional recovery after peripheral nerve injury.Biomedical reports · 2022Article
- The Effects of Nuclear Factor Erythroid 2 (NFE2)-Related Factor 2 (Nrf2) Activation in Preclinical Models of Peripheral Neuropathic Pain.Antioxidants (Basel, Switzerland) · 2022Review
- Gastrodin promotes the regeneration of peripheral nerves by regulating miR-497/BDNF axis.BMC complementary medicine and therapies · 2022Article
- Review: Myelin clearance is critical for regeneration after peripheral nerve injury.Frontiers in neurology · 2022Review
- Dexpanthenol reduces fibrosis and aids repair following nerve laceration and neurorrhaphy.Experimental and therapeutic medicine · 2021Article
- Deficiency of Nrf2 exacerbates white matter damage and microglia/macrophage levels in a mouse model of vascular cognitive impairment.Journal of neuroinflammation · 2020Article
- (-)-Epigallocatechin gallate-loaded polycaprolactone scaffolds fabricated using a 3D integrated moulding method alleviate immune stress and induce neurogenesis.Cell proliferation · 2020Article
- Promotion of microglial phagocytosis by tuftsin stimulates remyelination in experimental autoimmune encephalomyelitis.Molecular medicine reports · 2019Article
- Isoquercitrin promotes peripheral nerve regeneration through inhibiting oxidative stress following sciatic crush injury in mice.Annals of translational medicine · 2019Article
- Organic dust, causing both oxidative stress and Nrf2 activation, is phagocytized by bronchial epithelial cells.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Protective effects of sulforaphane in experimental vascular cognitive impairment: Contribution of the Nrf2 pathway.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- YAP and TAZ RegulateFrontiers in molecular neuroscience · 2019Article
- Reactive Oxygen Species and Nrf2: Functional and Transcriptional Regulators of Hematopoiesis.Oxidative medicine and cellular longevity · 2019Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Oxidative stress is generated in several peripheral nerve injury models. In response to oxidative stress, the transcription factor Nrf2 is activated to induce expression of antioxidant responsive element (ARE) genes. The role of Nrf2 in peripheral nerve injury has not been studied to date. In this study, we used a sciatic nerve crush model to examine how deletion of Nrf2 affects peripheral nerve degeneration and regeneration. Our study demonstrated that functional recovery in the Nrf2(-/-) mice were impaired compared to the wild type mice after sciatic nerve crush. Larger myelin debris were present in the distal nerve stump of the Nrf2(-/-) mice than in the wild type mice. The presence of larger myelin debris in the Nrf2(-/-) mice coincides with less macrophages accumulation in the distal nerve stump. Less accumulation of macrophages may have contributed to slower clearance of myelin and thus resulted in the presence of larger myelin debris. Meanwhile, axonal regeneration is comparatively lower in the Nrf2(-/-) mice than in the wild type mice. Even after 3months post the injury, more thinly myelinated axon fibers were present in the Nrf2(-/-) mice than in the wild type mice. Taken collectively, these data support the concept of therapeutic intervention with Nrf2 activators following nerve injury.
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