ReviewCell death & disease2013
Switching cell fate, ncRNAs coming to play.
Review in Cell death & disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
- Circ_0001741 regulates proliferation and invasion in ESCC via the miR-194-5p/E2F3 axis.World journal of surgical oncology · 2025Article
- The improved de Bruijn graph for multitask learning: predicting functions, subcellular localization, and interactions of noncoding RNAs.Briefings in bioinformatics · 2024Article
- Ensemble Deep Learning Based on Multi-level Information Enhancement and Greedy Fuzzy Decision for Plant miRNA-lncRNA Interaction Prediction.Interdisciplinary sciences, computational life sciences · 2021Article
- LINC00152 mediates CD8Journal of molecular histology · 2021Article
- RP11-874J12.4, a novel lncRNA, confers chemoresistance in human gastric cancer cells by sponging miR-3972 and upregulating SSR2 expression.American journal of translational research · 2021Article
- HOTAIR contributes to the carcinogenesis of gastric cancer via modulating cellular and exosomal miRNAs level.Cell death & disease · 2020Article
- RPITER: A Hierarchical Deep Learning Framework for ncRNA⁻Protein Interaction Prediction.International journal of molecular sciences · 2019Article
- Disordered p53-MALAT1 pathway is associated with recurrent miscarriage.The Kaohsiung journal of medical sciences · 2019Article
- Downregulated MALAT1 relates to recurrent pregnancy loss via sponging miRNAs.The Kaohsiung journal of medical sciences · 2018Article
- Epigenetics and bone diseases.Genetics research · 2018Review
- An Ultraconserved Element Containing lncRNA Preserves Transcriptional Dynamics and Maintains ESC Self-Renewal.Stem cell reports · 2018Article
- A novel circulating hsa_circ_0081001 act as a potential biomarker for diagnosis and prognosis of osteosarcoma.International journal of biological sciences · 2018Article
- Vigor of survival determinism: subtle evolutionary gradualism interspersed with robust phylogenetic leaping.Theory in biosciences = Theorie in den Biowissenschaften · 2017Article
- Long non-coding RNA-CRNDE: a novel regulator of tumor growth and angiogenesis in hepatoblastoma.Oncotarget · 2017Article
- The Roles of Long Non-Protein-Coding RNAs in Osteo-Adipogenic Lineage Commitment.International journal of molecular sciences · 2017Review
- The essentiality of non-coding RNAs in cell reprogramming.Non-coding RNA research · 2017Review
- Nothing in Evolution Makes Sense Except in the Light of Genomics: Read-Write Genome Evolution as an Active Biological Process.Biology · 2016Review
- Long non-coding RNA LINC00628 functions as a gastric cancer suppressor via long-range modulating the expression of cell cycle related genes.Scientific reports · 2016Article
- Non-coding landscapes of colorectal cancer.World journal of gastroenterology · 2015Review
- Roles for noncoding RNAs in cell-fate determination and regeneration.Nature structural & molecular biology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
Cell fate decision is a critical step during physiological development when embryonic stem cells commit to either becoming adult stem cells or somatic cells. Recent advances in reprogramming demonstrate that a similar set of transcription factors (TFs), which are important for maintaining the pluripotent state of stem cells, can also reprogram somatic cells to induced pluripotent stem cells (iPSCs). In addition, trans-differentiation, which entails the use of different sets of defined factors, whereby one type of somatic cell can be directly converted into another and even to cell types from different germ layers has become a parallel widely used approach for switching cell fate. All these progresses have provided powerful tools to manipulate cells for basic science and therapeutic purposes. Besides protein-based factors, non-coding RNAs (ncRNAs), particularly microRNAs and long ncRNAs, are also involved in cell fate determination, including maintaining self-renewal of pluripotent stem cells and directing cell lineage. Targeting specific ncRNAs represents an alternative promising approach to optimize cell-based disease modeling and regenerative therapy. Here we focus on recent advances of ncRNAs in cell fate decision, including ncRNA-induced iPSCs and lineage conversion. We also discuss some underlying mechanisms and implications in molecular pathogenesis of human diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.