ArticleJournal of natural products2013
Alkaloids from Microcos paniculata with cytotoxic and nicotinic receptor antagonistic activities.
Article in Journal of natural products, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Review
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- Targeted Delivery of Potent Chemical Drugs and RNAi to Drug-Resistant Breast Cancer Using RNA-Nanotechnology and RNA-Ligand Displaying Extracellular vesicles.RNA nanomed · 2024Article
- Therapeutic Role of Alkaloids and Alkaloid Derivatives in Cancer Management.Molecules (Basel, Switzerland) · 2023Review
- Strategies for the discovery of potential anticancer agents from plants collected from Southeast Asian tropical rainforests as a case study.Natural product reports · 2023Review
- Article
- Microgrewiapine C: Asymmetric Synthesis, Spectroscopic Data, and Configuration Assignment.Journal of natural products · 2022Article
- Osteogenic Potential of Mesenchymal Stem Cells from Adipose Tissue, Bone Marrow and Hair Follicle Outer Root Sheath in a 3D Crosslinked Gelatin-Based Hydrogel.International journal of molecular sciences · 2021Article
- Advances in phytochemical and modern pharmacological research ofPharmaceutical biology · 2020Review
- Integration of molecular networking and fingerprint analysis for studying constituents in Microctis Folium.PloS one · 2020Article
- Variations of Flavone Glycosides Profile Underscore the Necessity of Quality Control of Prepared Microctis Folium Slices.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Anti-Infective and Anti-Cancer Properties of theMolecules (Basel, Switzerland) · 2019Review
- Review
- An Ultra-High Performance Liquid Chromatography with Tandem Mass Spectrometry Method for Determination of 10 Alkaloids in Beagle Dog Plasma after the Oral Administration of theMolecules (Basel, Switzerland) · 2018Article
- Hepatoprotective Effect of Polyphenol-Enriched Fraction fromOxidative medicine and cellular longevity · 2017Article
- Investigation of Vietnamese plants for potential anticancer agents.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2014Article
- Potent cytotoxic arylnaphthalene lignan lactones from Phyllanthus poilanei.Journal of natural products · 2014Article
- Bioactive constituents of Indigofera spicata.Journal of natural products · 2013Article
- Bioactive flavaglines and other constituents isolated from Aglaia perviridis.Journal of natural products · 2013Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Microcos paniculata is a large shrub or small tree that grows in several countries in South and Southeast Asia. In the present study, three new piperidine alkaloids, microgrewiapines A-C (1-3), as well as three known compounds, inclusive of microcosamine A (4), 7'-(3',4'-dihydroxyphenyl)-N-[4-methoxyphenyl)ethyl]propenamide (5), and liriodenine (6), were isolated from cytotoxic fractions of the separate chloroform-soluble extracts of the stem bark, branches, and leaves of M. paniculata. Compounds 1-6 and 1a (microgrewiapine A 3-acetate) showed a range of cytotoxicity values against the HT-29 human colon cancer cell line. When evaluated for their effects on human α3β4 or α4β2 nicotinic acetylcholine receptors (nAChRs), several of these compounds were shown to be active as nAChR antagonists. As a result of this study, microgrewiapine A (1) was found to be a selective cytotoxic agent for colon cancer cells over normal colon cells and to exhibit nicotinic receptor antagonistic activity for both the hα3β4 and hα4β2 receptor subtypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.