ReviewCanadian journal of psychiatry. Revue canadienne de psychiatrie2013
The significance of at-risk or prodromal symptoms for bipolar I disorder in children and adolescents.
Review in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 61 citations in OpenAlex.
- Development and validation of a prognostic model and risk calculator for the estimation of bipolar-spectrum disorder risk in hospitalised adolescents with non-psychotic/non-bipolar mental disorders.Molecular psychiatry · 2026Article
- Advancing the prediction of factors associated with bipolar disorder risk: utilizing early recognition tools and polygenic risk scores.International journal of bipolar disorders · 2025Article
- Exosomal microRNA signatures in youth at clinical high risk for bipolar disorder.Frontiers in psychiatry · 2025Article
- Hypomania-Checklist-33: risk stratification and factor structure in a mixed psychiatric adolescent sample.International journal of bipolar disorders · 2024Article
- Clinical staging and the differential risks for clinical and functional outcomes in young people presenting for youth mental health care.BMC medicine · 2022Article
- Potential for prediction of psychosis and bipolar disorder in Child and Adolescent Mental Health Services: a longitudinal register study of all people born in Finland in 1987.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2022Article
- The clinical characterization of the adult patient with bipolar disorder aimed at personalization of management.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2022Article
- The mood disorder spectrum vs. schizophrenia decision tree: EDIPHAS research into the childhood and adolescence of 205 patients.BMC psychiatry · 2022Article
- A cohort study of adolescents with depression in China: tracking multidimensional outcomes and early biomarkers for intervention.General psychiatry · 2022Article
- Early detection of bipolar disorders and treatment recommendations for help-seeking adolescents and young adults: Findings of the Early Detection and Intervention Center Dresden.International journal of bipolar disorders · 2021Article
- Demographic and Clinical Characteristics, Including Subsyndromal Symptoms Across Bipolar-Spectrum Disorders in Adolescents.Journal of child and adolescent psychopharmacology · 2020Article
- Cohort profile: the Brain and Mind CentreBMJ open · 2020Article
- [Diagnostics and early recognition of bipolar disorders].Der Nervenarzt · 2020Review
- The Lausanne-Geneva cohort study of offspring of parents with mood disorders: methodology, findings, current sample characteristics, and perspectives.Social psychiatry and psychiatric epidemiology · 2017Article
- Toward the Definition of a Bipolar Prodrome: Dimensional Predictors of Bipolar Spectrum Disorders in At-Risk Youths.The American journal of psychiatry · 2016Article
- Is There a Bipolar Prodrome Among Children and Adolescents?Current psychiatry reports · 2016Article
- Article
- Type and duration of subsyndromal symptoms in youth with bipolar I disorder prior to their first manic episode.Bipolar disorders · 2014Article
- The Bipolar Prodrome Symptom Interview and Scale-Prospective (BPSS-P): description and validation in a psychiatric sample and healthy controls.Bipolar disorders · 2014Article
- Integrated neurobiology of bipolar disorder.Frontiers in psychiatry · 2014Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
While in the early identification and intervention of psychosis-specific instruments and risk criteria have been generated and validated, research into indicated preventive strategies for bipolar I disorder (BD I) has only recently gained momentum. As the first signs of BD I often start before adulthood, such efforts are especially important in the vulnerable pediatric population. Data are summarized regarding the presence and nature of potentially prodromal, that is, subsyndromal, symptoms prior to BD I, defined by first-episode mania, focusing on pediatric patients. Research indicates the possibility of early identification of youth at clinical high risk for BD. Support for this proposition comes from retrospective studies of BD I patients, as well as prospective studies of community samples, offspring of BD I subjects, youth with depressive disorders, and patients at high risk for psychosis or with bipolar spectrum disorders without lifetime history of mania. These data provide essential insight into potential signs and symptoms that may enable presyndromal identification of BD I in youth. However, except for offspring studies, broader prospective approaches that focus on youth at clinical high risk for BD I and on developing specific interviews and (or) rating scales and risk criteria are mostly missing, or in their early stage. More work is needed to determine valid and sufficiently specific clinical high-risk criteria, to distinguish risk factors, endophenotypes, and comorbidities from prodromal symptomatology, and to develop phase-specific interventions that titrate the risk of intervention to the risk of transition to mania and to functional impairment or distress. Moreover, studies are needed that determine potential differences in prodromal symptoms and trajectories between children, adolescents, and adults, and the best phase-specific interventions.
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