ArticleBehavioural brain research2013
Developmentally divergent effects of Rho-kinase inhibition on cocaine- and BDNF-induced behavioral plasticity.
Article in Behavioural brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- The potential therapeutic roles of Rho GTPases in substance dependence.Frontiers in molecular neuroscience · 2023Article
- The effects of cocaine exposure in adolescence: Behavioural effects and neuroplastic mechanisms in experimental models.British journal of pharmacology · 2022Review
- Review
- β1-Integrins in the Developing Orbitofrontal Cortex Are Necessary for Expectancy Updating in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Rho-kinase inhibition has antidepressant-like efficacy and expedites dendritic spine pruning in adolescent mice.Neurobiology of disease · 2019Article
- Maturational Changes in Prefrontal and Amygdala Circuits in Adolescence: Implications for Understanding Fear Inhibition during a Vulnerable Period of Development.Brain sciences · 2019Review
- Impact of Sleep and Circadian Rhythms on Addiction Vulnerability in Adolescents.Biological psychiatry · 2018Review
- Prefrontal cortical BDNF: A regulatory key in cocaine- and food-reinforced behaviors.Neurobiology of disease · 2016Review
- Developmental DSP4 effects on cortical Arc expression.Neuroscience letters · 2016Article
- Non-muscle myosin II in disease: mechanisms and therapeutic opportunities.Disease models & mechanisms · 2015Review
- Synaptic Cytoskeletal Plasticity in the Prefrontal Cortex Following Psychostimulant Exposure.Traffic (Copenhagen, Denmark) · 2015Review
- GABAAα1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Plasticity in the prefrontal cortex of adult rats.Frontiers in cellular neuroscience · 2015Review
- Early-life cocaine interferes with BDNF-mediated behavioral plasticity.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- The orbitofrontal cortex regulates outcome-based decision-making via the lateral striatum.The European journal of neuroscience · 2013Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Prefrontal cortical dendritic spine remodeling during adolescence may open a window of vulnerability to pathological stimuli that impact long-term behavioral outcomes, but causal mechanisms remain unclear. We administered the Rho-kinase inhibitor HA-1077 during three adolescent periods in mice to destabilize dendritic spines. In adulthood, cocaine-induced locomotor activity was exaggerated. By contrast, when administered in adulthood, HA-1077 had no psychomotor consequences and normalized food-reinforced instrumental responding after orbitofrontal-selective knockdown of Brain-derived neurotrophic factor, a potential factor in addiction. Thus, early-life Rho-kinase inhibition confers cocaine vulnerability, but may actually protect against pathological reward-seeking - particularly in cases of diminished neurotrophic support - in adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.