ArticleTheoretical biology & medical modelling2013
Stem cell biology is population biology: differentiation of hematopoietic multipotent progenitors to common lymphoid and myeloid progenitors.
Article in Theoretical biology & medical modelling, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- What Do We Know About Immune System Aging from Human and Animal Studies?International journal of molecular sciences · 2026Review
- Subverting the Canon: Novel Cancer-Promoting Functions and Mechanisms for snoRNAs.International journal of molecular sciences · 2024Review
- Influential factors for optimizing and strengthening mesenchymal stem cells and hematopoietic stem cells co-culture.Molecular biology reports · 2024Review
- Age-associated changes in innate and adaptive immunity: role of the gut microbiota.Frontiers in immunology · 2024Review
- Beyond lymphopenia, unraveling radiation-induced leucocyte subpopulation kinetics and mechanisms through modeling approaches.Journal of experimental & clinical cancer research : CR · 2023Review
- The horizon of bone organoid: A perspective on construction and application.Bioactive materials · 2022Review
- 20(S)-Protopanaxdiol Suppresses the Abnormal Granule-Monocyte Differentiation of Hematopoietic Stem Cells in 4T1 Breast Cancer-Bearing Mouse.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Clonal hematopoiesis of indeterminate potential and its impact on patient trajectories after stem cell transplantation.PLoS computational biology · 2019Article
- Identifying niche-mediated regulatory factors of stem cell phenotypic state: a systems biology approach.FEBS letters · 2017Review
- Feedback mechanisms control coexistence in a stem cell model of acute myeloid leukaemia.Journal of theoretical biology · 2016Article
- Feedback control in planarian stem cell systems.BMC systems biology · 2016Article
- Cellular population dynamics control the robustness of the stem cell niche.Biology open · 2015Article
- Stochastic dynamics of interacting haematopoietic stem cell niche lineages.PLoS computational biology · 2014Article
- Interactions and tradeoffs between cell recruitment, proliferation, and differentiation affect CNS regeneration.Biophysical journal · 2014Article
- Mathematical model of adult stem cell regeneration with cross-talk between genetic and epigenetic regulation.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
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Authors and funding
2 authors.
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Abstract
The hematopoietic stem cell (HSC) system is a demand control system, with the demand coming from the organism, since the products of the common myeloid and lymphoid progenitor (CMP, CLP respectively) cells are essential for activity and defense against disease. We show how ideas from population biology (combining population dynamics and evolutionary considerations) can illuminate the feedback control of the HSC system by the fully differentiated products, which has recently been verified experimentally. We develop models for the penultimate differentiation of HSC Multipotent Progenitors (MPPs) into CLP and CMP and introduce two concepts from population biology into stem cell biology. The first concept is the Multipotent Progenitor Commitment Response (MPCR) which is the probability that a multipotent progenitor cell follows a CLP route rather than a CMP route. The second concept is the link between the MPCR and a measure of Darwinian fitness associated with organismal performance and the levels of differentiated lymphoid and myeloid cells. We show that many MPCRs are consistent with homeostasis, but that they will lead to different dynamics of cells and signals following a wound or injury and thus have different consequences for Darwinian fitness. We show how coupling considerations of life history to dynamics of the HSC system and its products allows one to compute the selective pressures on cellular processes. We discuss ways that this framework can be used and extended.
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