Evidence map›Paper›PMID 23327471›Full record

ReviewExpert opinion on biological therapy2013

Biomaterials and stem cells for tissue engineering.

Zhanpeng Zhang, Melanie J Gupte, Peter X Ma

Open access · greenAbstract readReview
In one paragraph

Review in Expert opinion on biological therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 65 citations in OpenAlex.

  1. Review
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  19. Connecting secretome to hematopoietic stem cell phenotype shifts in an engineered bone marrow niche.Integrative biology : quantitative biosciences from nano to macro · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Zhanpeng ZhangDepartment of Biomedical Engineering, Ann Arbor, MI 48109-1078, USA.
Melanie J Gupte
Peter X Ma
University of Michigan–Ann Arbor · US

Funding

Tissue Engineering and RegenerationT32DE007057 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID H. KOHN · 1985 to 2026
$17.3M
PTH and Calcium Synergy for Craniofacial RegenerationR01DE022327 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCAULEY, LAURIE K. · 2012 to 2022
$3.8M
Periodontal Engineering Using Biomimetic Nano ScaffoldsR01DE015384 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MA, PETER X · 2003 to 2011
$2.9M
Orchestrating Bone Regeneration on Multiple ScalesR01DE017689 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MA, PETER X · 2007 to 2010
$1.4M
NIDCR NIH HHS DE015384NIDCR NIH HHS DE017689NIDCR NIH HHS DE022327NIDCR NIH HHS R01 DE015384NIDCR NIH HHS R01 DE017689NIDCR NIH HHS R01 DE022327NIDCR NIH HHS T32 DE007057NIDCR NIH HHS T32DE 007057
6 · The paper itself

Abstract

introductionOrgan failure and tissue loss are challenging health issues due to widespread injury, the lack of organs for transplantation and limitations of conventional artificial implants. The field of tissue engineering aims to provide alternative living substitutes that restore, maintain or improve tissue function. AREAS COVERED: In this paper, a wide range of porous scaffolds are reviewed, with an emphasis on phase-separation techniques that generate advantageous nanofibrous 3D scaffolds for stem cell-based tissue engineering applications. In addition, methods for presentation and delivery of bioactive molecules to mimic the properties of stem cell niches are summarized. Recent progress in using these bioinstructive scaffolds to support stem cell differentiation and tissue regeneration is also presented. EXPERT OPINION: Stem cells have great clinical potential because of their capability to differentiate into multiple cell types. Biomaterials have served as artificial extracellular environments to regulate stem cell behavior. Biomaterials with various physical, mechanical and chemical properties can be designed to control stem cell development for regeneration.

conclusionThe research at the interface of stem cell biology and biomaterials has made and will continue to make exciting advances in tissue engineering.

Indexed as

AnimalsBiocompatible MaterialsCell DifferentiationHumansRegenerationStem Cell NicheStem CellsSurface PropertiesTissue EngineeringBiocompatible Materials

Identifiers

PMID23327471
PMCPMC3596493
OpenAlexW1981475194

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.