ArticleActa oncologica (Stockholm, Sweden)2013
Stillbirth, early death and neonatal morbidity among offspring of female cancer survivors.
Article in Acta oncologica (Stockholm, Sweden), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Obstetric Complications and Pregnancy Outcomes in Cancer Survivors: A Systematic Review and Meta-Analysis.Cancers · 2025Review
- Perinatal and childhood outcomes of children born to female cancer survivors in South Korea.Scientific reports · 2024Article
- A bibliometric study on clinical research in neonatal encephalopathy.Frontiers in pediatrics · 2024Review
- Outcomes of Pregnancies and Deliveries of Patients Who Underwent Fertility-Preserving Surgery for Early-Stage Epithelial Ovarian Cancer.Journal of clinical medicine · 2022Article
- Early-life cancer, infertility, and risk of adverse pregnancy outcomes: a registry linkage study in Massachusetts.Cancer causes & control : CCC · 2021Article
- ESHRE guideline: female fertility preservation.Human reproduction open · 2020Article
- Best Practices in Counseling Young Female Cancer Survivors on Reproductive Health.Seminars in reproductive medicine · 2017Review
- Vaginal delivery after hemipelvectomy and pelvic radiotherapy for chondrosarcoma.BMJ case reports · 2014Article
- Adverse obstetric and perinatal outcomes following treatment of adolescent and young adult cancer: a population-based cohort study.PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundIncreased awareness of the adverse effects of cancer treatments has prompted the development of fertility preserving regimens for the growing population of cancer survivors who desire to have children of their own. MATERIAL AND
methodsWe conducted a registry-based study to evaluate the risk of stillbirth, early death and neonatal morbidity among children of female cancer survivors (0-34 years at diagnosis) compared with children of female siblings. A total of 3501 and 16 908 children of female cancer patients and siblings, respectively, were linked to the national medical birth and cause-of-death registers.
resultsThe risk of stillbirth or early death was not significantly increased among offspring of cancer survivors as compared to offspring of siblings: the risk [Odds Ratio (OR)] of early neonatal death, i.e. mortality within the first week was 1.35, with a 95% confidence interval (CI) of 0.58-3.18, within 28 days 1.40, 95% CI 0.46-4.24 and within the first year of life 1.11, 95% CI 0.64-1.93 after adjustment for the main explanatory variables. All these risk estimates were reduced towards one after further adjustment for duration of pregnancy. Measures of serious neonatal morbidity were not significantly increased among the children of survivors. However, there was a significant increase in the monitoring of children of cancer survivors for neonatal conditions (OR 1.56, 95% CI 1.35-1.80), which persisted even after correcting for duration of pregnancy, that might be related to parental cancer and its treatment or increased surveillance among the children.
conclusionOffspring of cancer survivors were more likely to require monitoring or care in a neonatal intensive care unit, but the risk of early death or stillbirth was not increased after adjustment for prematurity. Due to the rarity of the mortality outcomes studied, collaborative studies may be helpful in ruling out the possibility of an increased risk among offspring of cancer survivors.
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