ArticleAdvanced biomedical research2012
High prevalence of congenital hypothyroidism in Isfahan: Do familial components have a role?
Article in Advanced biomedical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- InvestigatingFrontiers in endocrinology · 2025Article
- Prevalence of Transient Hypothyroidism in Children Diagnosed with Congenital Hypothyroidism between 2000 and 2016.International journal of molecular sciences · 2023Article
- The Consensus on the Diagnosis and Management of Congenital Hypothyroidism in Term Neonates.International journal of preventive medicine · 2023Review
- The association between familial and environmental factors and prevalence of congenital hypothyroidism in center of Iran.Environmental science and pollution research international · 2021Article
- Congenital hypothyroidism in different cities of the Isfahan province: A descriptive retrospective study.Journal of education and health promotion · 2019Article
- The incidence of congenital hypothyroidism (CH) in Guangxi, China and the predictors of permanent and transient CH.Endocrine connections · 2017Article
- Thyroid dysfunction and developmental anomalies in first degree relatives of children with thyroid dysgenesis.World journal of pediatrics : WJP · 2016Article
- Epidemiology of congenital hypothyroidism in Markazi Province, Iran.Journal of clinical research in pediatric endocrinology · 2014Article
- Growth and specialized growth charts of children with congenital hypothyroidism detected by neonatal screening in isfahan, iran.ISRN endocrinology · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite elimination of iodine deficiency, the rates of both permanent and transient congenital hypothyroidism (CH) in our study were higher than the comparable worldwide rates, which emphasize the major role of genetic factors in the pathogenesis of CH and many studies in this regard confirm this possibility. MATERIALS AND
methodsIn this review, we report all studies that established during CH screening program regarding familial and genetic component of the disease.
resultsAlthough we could not entirely ignore the possible role of environmental and autoimmune factors in the development and function of thyroid gland, our findings strongly suggest the role of genetic factors as dominant etiologic factor in CH.
conclusionThe studies support the existence of a familial component of CH involving dominant genetic predisposition factors with a low penetrance. Considering the polygenic/multifactorial basis of CH, they suggest the possible involvement of other unknown genes in the pathogenesis of the disease, which may also follow non-Mendelian pattern of inheritance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.