ArticleArthritis2012
A review of translational animal models for knee osteoarthritis.
Article in Arthritis, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
124 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Initiating factors for the onset of OA: A systematic review of animal bone and cartilage pathology in OA.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Pooled it
- Species-specific inflammatory responses of chondrocytes: Toward evidence-based model selection in OA research.iScience · 2026Article
- Arthroscopic Anterior Cruciate Ligament Transection for Osteoarthritis Induction in Rabbits: A Pilot Feasibility and Characterization Study.Medicina (Kaunas, Lithuania) · 2026Article
- Article
- Development of a sheep model of knee osteoarthritis and preliminary magnetic resonance-guided focused ultrasound evaluation.Animal models and experimental medicine · 2026Article
- MiRNA-Mediated Regulation in Osteoarthritis Across Joint Tissues, Including Translational Perspectives in Dogs.Animals : an open access journal from MDPI · 2026Review
- Mammalian cell-derived extracellular vesicles remodel the immune-repair microenvironment in osteoarthritis: from pathological signal transmission to regenerative therapy.Frontiers in immunology · 2026Review
- Evaluating Knee Osteoarthritis Induction Methods in Small Translational Animal Models from 1970-2025: A Comprehensive Systematic Review.The archives of bone and joint surgery · 2026Review
- Ex vivo robotic measurement of the acute biomechanical impact of anterior cruciate ligament rupture in rats.Journal of biomechanics · 2025Article
- A Review of Rodent Behavior, Mobility, and Pain Modifications in Response to Destabilization of the Medial Meniscus Injury.Biomedicines · 2025Review
- Thick or Thin? Implications of Cartilage Architecture for Osteoarthritis Risk in Sedentary Lifestyles.Biomedicines · 2025Review
- Morphometric analysis of rat and mouse musculoskeletal tissues using high field MRI.Scientific reports · 2025Article
- Beyond symptomatic alignment: evaluating the integration of causal mechanisms in matching animal models with human pathotypes in osteoarthritis research.Arthritis research & therapy · 2025Review
- Article
- The Modified Canine Groove Model of Osteoarthritis.Biomedicines · 2025Article
- Determination of the miRNA profile of extracellular vesicles from equine mesenchymal stem cells after different treatments.Stem cell research & therapy · 2025Article
- An Abbreviated Rabbit Knee Model of Joint Contracture.Tissue engineering. Part C, Methods · 2025Article
- Development of a Novel Rat Knee Osteoarthritis Model Induced by Medial Meniscus Extrusion.Cartilage · 2025Article
- Multiscale correlations between joint and tissue-specific biomechanics and anatomy in postmortem ovine stifles.Scientific reports · 2025Article
64 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knee osteoarthritis remains a tremendous public health concern, both in terms of health-related quality of life and financial burden of disease. Translational research is a critical step towards understanding and mitigating the long-term effects of this disease process. Animal models provide practical and clinically relevant ways to study both the natural history and response to treatment of knee osteoarthritis. Many factors including size, cost, and method of inducing osteoarthritis are important considerations for choosing an appropriate animal model. Smaller animals are useful because of their ease of use and cost, while larger animals are advantageous because of their anatomical similarity to humans. This evidence-based review will compare and contrast several different animal models for knee osteoarthritis. Our goal is to inform the clinician about current research models, in order to facilitate the transfer of knowledge from the "bench" to the "bedside."
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.