ArticleeLife2013
Dual functions of TAF7L in adipocyte differentiation.
Article in eLife, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 46 citations in OpenAlex.
- Defining the role of 2,2',4,4'-tetrabromodiphenyl ether in 3T3-L1 cellular differentiation by transcriptome sequencing analysis.Adipocyte · 2024Article
- TAF7L regulates early stages of male germ cell development in the rat.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- The downstream PPARγ target LRRC1 participates in early stage adipocytic differentiation.Molecular and cellular biochemistry · 2023Article
- Low temperature upregulating HSP70 expression to mitigate the paclitaxel-induced damages in NHEK cell.PeerJ · 2023Article
- Genetic characterization of a missense mutation in the X-linked TAF7L gene identified in an oligozoospermic man†.Biology of reproduction · 2022Article
- Identification of differentially distributed gene expression and distinct sets of cancer-related genes identified by changes in mean and variability.NAR genomics and bioinformatics · 2022Article
- TAF4b transcription networks regulating early oocyte differentiation.Development (Cambridge, England) · 2022Article
- Role and Clinical Utility of Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma.Cancers · 2021Review
- Sequence and chromatin determinants of transcription factor binding and the establishment of cell type-specific binding patterns.Biochimica et biophysica acta. Gene regulatory mechanisms · 2020Review
- Poorly controlled diabetes mellitus alters placental structure, efficiency, and plasticity.BMJ open diabetes research & care · 2020Article
- Dynamic and regulated TAF gene expression during mouse embryonic germ cell development.PLoS genetics · 2020Article
- Transcription start site analysis reveals widespread divergent transcription in D. melanogaster and core promoter-encoded enhancer activities.Nucleic acids research · 2018Article
- The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo.Development (Cambridge, England) · 2017Article
- Hierarchical role for transcription factors and chromatin structure in genome organization along adipogenesis.The FEBS journal · 2017Article
- Elevated TATA-binding protein expression drives vascular endothelial growth factor expression in colon cancer.Oncotarget · 2017Article
- Drosophila TRF2 and TAF9 regulate lipid droplet size and phospholipid fatty acid composition.PLoS genetics · 2017Article
- Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis.eLife · 2016Article
- Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation.Nature communications · 2016Article
- Article
- A specific E3 ligase/deubiquitinase pair modulates TBP protein levels during muscle differentiation.eLife · 2015Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
The diverse transcriptional mechanisms governing cellular differentiation and development of mammalian tissue remains poorly understood. Here we report that TAF7L, a paralogue of TFIID subunit TAF7, is enriched in adipocytes and white fat tissue (WAT) in mouse. Depletion of TAF7L reduced adipocyte-specific gene expression, compromised adipocyte differentiation, and WAT development as well. Ectopic expression of TAF7L in myoblasts reprograms these muscle precursors into adipocytes upon induction. Genome-wide mRNA-seq expression profiling and ChIP-seq binding studies confirmed that TAF7L is required for activating adipocyte-specific genes via a dual mechanism wherein it interacts with PPARγ at enhancers and TBP/Pol II at core promoters. In vitro binding studies confirmed that TAF7L forms complexes with both TBP and PPARγ. These findings suggest that TAF7L plays an integral role in adipocyte gene expression by targeting enhancers as a cofactor for PPARγ and promoters as a component of the core transcriptional machinery.DOI:http://dx.doi.org/10.7554/eLife.00170.001.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.