ArticleCurrent cardiovascular risk reports2013
Systems Biology Approaches and Applications in Obesity, Diabetes, and Cardiovascular Diseases.
Article in Current cardiovascular risk reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Metabolic Inflammation as a Common Thread in Cardio-Endocrine Diseases: Toward a Unified Therapeutic Framework.Cureus · 2026Review
- Gene Regulatory Networks in Coronary Artery Disease.Current atherosclerosis reports · 2023Review
- Childhood Obesity and the Cryptic Language of the Microbiota: Metabolomics' Upgrading.Metabolites · 2023Review
- Multitissue Multiomics Systems Biology to Dissect Complex Diseases.Trends in molecular medicine · 2020Review
- Network Modeling Approaches and Applications to Unravelling Non-Alcoholic Fatty Liver Disease.Genes · 2019Review
- SyNDI: synchronous network data integration framework.BMC bioinformatics · 2018Article
- Mini-Review: The Contribution of Intermediate Phenotypes to GxE Effects on Disorders of Body Composition in the New OMICS Era.International journal of environmental research and public health · 2017Review
- The Munich MIDY Pig Biobank - A unique resource for studying organ crosstalk in diabetes.Molecular metabolism · 2017Article
- Multidimensional Integrative Genomics Approaches to Dissecting Cardiovascular Disease.Frontiers in cardiovascular medicine · 2017Review
- Vascular Endothelial Regulation of Obesity-Associated Insulin Resistance.Frontiers in cardiovascular medicine · 2017Review
- Molecular and genetic inflammation networks in major human diseases.Molecular bioSystems · 2016Review
- Diabetes and cardiovascular disease: let's push forward with translational research.Cardiovascular diagnosis and therapy · 2015Article
- Nutritional systems biology of type 2 diabetes.Genes & nutrition · 2015Article
- Network-based association of hypoxia-responsive genes with cardiovascular diseases.New journal of physics · 2014Article
- Current advances in systems and integrative biology.Computational and structural biotechnology journal · 2014Review
- Genetic associations with micronutrient levels identified in immune and gastrointestinal networks.Genes & nutrition · 2014Article
- The pathogenesis of obesity from a genomic and systems biology perspective.The Yale journal of biology and medicine · 2014Review
- Systems Epidemiology: A New Direction in Nutrition and Metabolic Disease Research.Current nutrition reports · 2013Article
- Perspective: a systems approach to diabetes research.Frontiers in genetics · 2013Review
- Metabolomics and fetal-neonatal nutrition: between "not enough" and "too much".Molecules (Basel, Switzerland) · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The metabolically connected triad of obesity, diabetes, and cardiovascular diseases is a major public health threat, and is expected to worsen due to the global shift toward energy-rich and sedentary living. Despite decades of intense research, a large part of the molecular pathogenesis behind complex metabolic diseases remains unknown. Recent advances in genetics, epigenomics, transcriptomics, proteomics and metabolomics enable us to obtain large-scale snapshots of the etiological processes in multiple disease-related cells, tissues and organs. These datasets provide us with an opportunity to go beyond conventional reductionist approaches and to pinpoint the specific perturbations in critical biological processes. In this review, we summarize systems biology methodologies such as functional genomics, causality inference, data-driven biological network construction, and higher-level integrative analyses that can produce novel mechanistic insights, identify disease biomarkers, and uncover potential therapeutic targets from a combination of omics datasets. Importantly, we also demonstrate the power of these approaches by application examples in obesity, diabetes, and cardiovascular diseases.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.