ArticlePloS one2013
Mediator subunit18 controls flowering time and floral organ identity in Arabidopsis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 57 citations in OpenAlex.
- Phosphate deprivation counteracts the cell death caused by loss-of-function of MEDIATOR 18 in Arabidopsis root meristems.Protoplasma · 2026Article
- The role of mediator subunit MED7 in Arabidopsis development.Frontiers in plant science · 2025Article
- Pseudomonas syringae infectivity correlates to altered transcript and metabolite levels of Arabidopsis mediator mutants.Scientific reports · 2024Article
- Chromosome-level genome assembly and population genomics of Robinia pseudoacacia reveal the genetic basis for its wide cultivation.Communications biology · 2023Article
- Identification of novel loci for flowering time in mungbean [Vigna radiata (L.) R. Wilczek] using genome-wide association study.Genes & genomics · 2023Article
- Functional Analysis ofFrontiers in plant science · 2021Article
- The Important Function of Mediator Complex in Controlling the Developmental Transitions in Plants.International journal of molecular sciences · 2020Review
- Specific functions for Mediator complex subunits from different modules in the transcriptional response of Arabidopsis thaliana to abiotic stress.Scientific reports · 2020Article
- Candidate Variants for Additive and Interactive Effects on Bioenergy Traits in Switchgrass (The plant genome · 2018Article
- Mediator subunit MED31 is required for radial patterning ofProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Silencing SlMED18, tomato Mediator subunit 18 gene, restricts internode elongation and leaf expansion.Scientific reports · 2018Article
- An Arabidopsis Nucleoporin NUP85 modulates plant responses to ABA and salt stress.PLoS genetics · 2017Article
- Papillae formation on trichome cell walls requires the function of the mediator complex subunit Med25.Plant molecular biology · 2017Article
- The Multitalented MEDIATOR25.Frontiers in plant science · 2017Review
- MEDIATOR18 and MEDIATOR20 confer susceptibility to Fusarium oxysporum in Arabidopsis thaliana.PloS one · 2017Article
- Functional metabolomics as a tool to analyze Mediator function and structure in plants.PloS one · 2017Article
- Redox regulation of the MED28 and MED32 mediator subunits is important for development and senescence.Protoplasma · 2016Article
- An Integrated Genomic Strategy Delineates Candidate Mediator Genes Regulating Grain Size and Weight in Rice.Scientific reports · 2016Article
- Epigenomics and bolting tolerance in sugar beet genotypes.Journal of experimental botany · 2016Article
- Identification of MEDIATOR16 as the Arabidopsis COBRA suppressor MONGOOSE1.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Mediator is a conserved multi-protein complex that plays an important role in regulating transcription by mediating interactions between transcriptional activator proteins and RNA polymerase II. Much evidence exists that Mediator plays a constitutive role in the transcription of all genes transcribed by RNA polymerase II. However, evidence is mounting that specific Mediator subunits may control the developmental regulation of specific subsets of RNA polymerase II-dependent genes. Although the Mediator complex has been extensively studied in yeast and mammals, only a few reports on Mediator function in flowering time control of plants, little is known about Mediator function in floral organ identity. Here we show that in Arabidopsis thaliana, MEDIATOR SUBUNIT 18 (MED18) affects flowering time and floral organ formation through FLOWERING LOCUS C (FLC) and AGAMOUS (AG). A MED18 loss-of-function mutant showed a remarkable syndrome of later flowering and altered floral organ number. We show that FLC and AG mRNA levels and AG expression patterns are altered in the mutant. Our results support parallels between the regulation of FLC and AG and demonstrate a developmental role for Mediator in plants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.