ArticlePloS one2013
Asymptomatic cattle naturally infected with Mycobacterium bovis present exacerbated tissue pathology and bacterial dissemination.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 59 citations in OpenAlex.
- Histopathological patterns of bovine tuberculosis in cattle slaughtered in Southern Brazil: correlation with molecular detection of Mycobacterium spp.Veterinary research communications · 2026Article
- Strategy for Improving the Diagnostic Efficacy of Bovine Tuberculosis Using a Novel PCRVeterinary research communications · 2026Article
- Breed-specific innate immune responses to Brucella abortus strain RB51 and Bacillus Calmette-Guérin in cattle.Scientific reports · 2026Article
- Transcriptomic insights intoThe veterinary quarterly · 2025Article
- BLV coinfection impairs immunity and diagnostics in bovine tuberculosis.Scientific reports · 2025Article
- Bovine tuberculosis in Central Ethiopian slaughterhouses and the identification of causative mycobacteria by multiplex real-time PCR.BMC microbiology · 2024Article
- Unveiling insights into bovine tuberculosis: A comprehensive review.Open veterinary journal · 2024Review
- Performance of post-mortem diagnostic tests for tuberculosis in wild ungulates at low and high prevalence assessed using Bayesian latent class models.Frontiers in veterinary science · 2024Article
- Limited usefulness of the ISFrontiers in veterinary science · 2024Article
- Combination with Annual Deworming Treatments Does Not Enhance the Effects of PCV2 Vaccination on the Development of TB in Wild Boar Populations.Animals : an open access journal from MDPI · 2023Article
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- Comparative pathology of experimental pulmonary tuberculosis in animal models.Frontiers in veterinary science · 2023Review
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- The Bovine Tuberculoid Granuloma.Pathogens (Basel, Switzerland) · 2022Review
- Histopathologic differences in granulomas ofFrontiers in microbiology · 2022Article
- The Role of Histopathology as a Complementary Diagnostic Tool in the Monitoring of Bovine Tuberculosis.Frontiers in veterinary science · 2022Article
- Direct PCR on Tissue Samples To Detect Mycobacterium tuberculosis Complex: an Alternative to the Bacteriological Culture.Journal of clinical microbiology · 2021Article
- Real-Time PCR Validation forFrontiers in veterinary science · 2021Article
- Protective Effect of Intestinal Helminthiasis Against Tuberculosis Progression Is Abrogated by Intermittent Food Deprivation.Frontiers in immunology · 2021Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Rational discovery of novel immunodiagnostic and vaccine candidate antigens to control bovine tuberculosis (bTB) requires knowledge of disease immunopathogenesis. However, there remains a paucity of information on the Mycobacterium bovis-host immune interactions during the natural infection. Analysis of 247 naturally PPD+ M. bovis-infected cattle revealed that 92% (n = 228) of these animals were found to display no clinical signs, but presented severe as well as disseminated bTB-lesions at post-mortem examination. Moreover, dissemination of bTB-lesions positively correlated with both pathology severity score (Spearman r = 0.48; p<0.0001) and viable tissue bacterial loads (Spearman r = 0.58; p = 0.0001). Additionally, granuloma encapsulation negatively correlated with M. bovis growth as well as pathology severity, suggesting that encapsulation is an effective mechanism to control bacterial proliferation during natural infection. Moreover, multinucleated giant cell numbers were found to negatively correlate with bacterial counts (Spearman r = 0.25; p = 0.03) in lung granulomas. In contrast, neutrophil numbers in the granuloma were associated with increased M. bovis proliferation (Spearman r = 0.27; p = 0.021). Together, our findings suggest that encapsulation and multinucleated giant cells control M. bovis viability, whereas neutrophils may serve as a cellular biomarker of bacterial proliferation during natural infection. These data integrate host granuloma responses with mycobacterial dissemination and could provide useful immunopathological-based biomarkers of disease severity in natural infection with M. bovis, an important cattle pathogen.
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